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The damage to RGCs in glaucoma occurs by various mechanisms, including elevated intraocular pressure, oxidative stress, inflammation, and other neurodegenerative processes. As the disease progresses, the loss of RGCs leads to vision loss. Therefore, protecting RGCs from damage and promoting their survival are important goals in managing glaucoma. In this regard, resveratrol (RES), a polyphenolic phytoalexin, exerts antioxidant effects and slows down the evolution and progression of glaucoma. The present review shows that RES plays a protective role in RGCs in cases of ischemic injury and hypoxia as well as in ErbB2 protein expression in the retina. Additionally, RES plays protective roles in RGCs by promoting cell growth, reducing apoptosis, and decreasing oxidative stress in H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>\u2010exposed RGCs. RES was also found to inhibit oxidative stress damage in RGCs and suppress the activation of mitogen\u2010activated protein kinase signaling pathways. RES could alleviate retinal function impairment by suppressing the hypoxia\u2010inducible factor\u20101 alpha\/vascular endothelial growth factor and p38\/p53 axes while stimulating the PI3K\/Akt pathway. Therefore, RES might exert potential therapeutic effects for managing glaucoma by protecting RGCs from damage and promoting their survival.<\/jats:p>","DOI":"10.1002\/ame2.12438","type":"journal-article","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T09:24:19Z","timestamp":1716974659000},"page":"195-207","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Neuroprotective effects of resveratrol on retinal ganglion cells in glaucoma in rodents: A narrative review"],"prefix":"10.1002","volume":"7","author":[{"given":"Maryam","family":"Golmohammadi","sequence":"first","affiliation":[{"name":"School of Medicine Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Arash Aghaei","family":"Meibodi","sequence":"additional","affiliation":[{"name":"School of Medicine Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sulieman Ibraheem Shelash","family":"Al\u2010Hawary","sequence":"additional","affiliation":[{"name":"Department of Business Administration, Business School Al al\u2010Bayt University  Mafraq Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jitendra","family":"Gupta","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Research GLA University  Mathura India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrohim B.","family":"Sapaev","sequence":"additional","affiliation":[{"name":"Tashkent Institute of Irrigation and Agricultural Mechanization Engineers  Tashkent Uzbekistan"},{"name":"New Uzbekistan University  Tashkent Uzbekistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazin A. 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