{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T20:57:45Z","timestamp":1792357065512,"version":"4.4.0"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFF0702402"],"award-info":[{"award-number":["2021YFF0702402"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anim Models and Exp Med"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Species of the genus\n                      <jats:italic>Eimeria<\/jats:italic>\n                      cause coccidiosis in chickens, resulting in a huge burden to the poultry industry worldwide.\n                      <jats:italic>Eimeria tenella<\/jats:italic>\n                      is one of the most prevalent chicken coccidia in China, and\n                      <jats:italic>E. tenella<\/jats:italic>\n                      infection causes hemorrhagic cecitis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Using an established model of coccidiosis in chickens combined with necropsy, imaging of pathological tissue sections, and other techniques, we evaluated the gross and microscopic lesions of cecal tissue within 15\u2009days after inoculation with sporulated oocysts and described the endogenetic developmental process and relationship between\n                      <jats:italic>E<\/jats:italic>\n                      .\n                      <jats:italic>tenella<\/jats:italic>\n                      infection and enteritis development in chickens.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We observed three generations of merogony and gamogony in\n                      <jats:italic>E<\/jats:italic>\n                      .\n                      <jats:italic>tenella<\/jats:italic>\n                      . We observed gross lesions in the cecum from 84 hpi (hours post inoculation) and microscopic lesions from 60 hpi. The lesions in the cecum mainly exhibited hemorrhagic enteritis. Their severity increased with the onset of the second generation of merogony. The lesions began to alleviate by the end of the endogenous stages of\n                      <jats:italic>E<\/jats:italic>\n                      .\n                      <jats:italic>tenella<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      We show, for the first time, the complete observation of a series of changes in enteritis caused by 5\u2009\u00d7\u200910\n                      <jats:sup>3<\/jats:sup>\n                      <jats:italic>E<\/jats:italic>\n                      .\n                      <jats:italic>tenella<\/jats:italic>\n                      oocysts. This study provides reference materials for\n                      <jats:italic>E<\/jats:italic>\n                      .\n                      <jats:italic>tenella<\/jats:italic>\n                      research and pathological diagnosis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ame2.12463","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:38:55Z","timestamp":1729643935000},"page":"893-903","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Histopathologic observations in a coccidiosis model of\n                    <i>Eimeria tenella<\/i>"],"prefix":"10.1002","volume":"7","author":[{"given":"Zhixin","family":"Sun","sequence":"first","affiliation":[{"name":"National Key Laboratory of Veterinary Public Health and Safety, Key Laboratory of Animal Epidemiology of the Ministry of Agriculture and Rural Affairs, National Animal Transmissible 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