{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T19:12:01Z","timestamp":1774379521038,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T00:00:00Z","timestamp":1720483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anim Models and Exp Med"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>An increase in epidural pressure around the stenosis has been observed in patients with lumbar spinal stenosis (LSS) with positive signs of sedimentation or redundant nerve roots. Further analysis of the pressure conditions in the stenotic area would be of great interest. We hypothesized that it would be possible to determine the physiological parameters of the epidural pulse wave and its course in pathological stenosis as a basis for objective identification of LSS based on pressure using a new measuring method with continuous spatial and temporal resolution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a single\u2010case proof\u2010of\u2010principle in\u00a0vivo animal trial and used a newly developed hybrid pressure\u2010measurement probe with a fiber\u2010tip Fabry\u2013P\u00e9rot interferometer and several fiber Bragg gratings (FBG).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>With reproducible precision, we determined the mean epidural pressure to be 7.5\u2009mmHg and the peak\u2010to\u2010peak value to be 4\u20135\u2009mmHg. When analyzing the pressure measured by an FBG array, both the heart and respiratory rates can be precisely determined. This study was the first to measure the pulse wave velocity of the cerebrospinal fluid pressure wave as 0.97\u2009m\/s using the newly developed pressure probe. A simulated LSS was detected in real time and located exactly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The developed fiber\u2010optic pressure sensor probe enables a new objective measurement of epidural pressure. We confirmed our hypothesis that physiological parameters of the epidural pulse wave can be determined and that it is possible to identify an LSS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ame2.12469","type":"journal-article","created":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T01:07:10Z","timestamp":1720573630000},"page":"769-776","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Epidural pressure measurement using a fiber\u2010optic sensor (proof\u2010of\u2010principle in\u00a0vivo animal trial)"],"prefix":"10.1002","volume":"7","author":[{"given":"Susanne","family":"Barz","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy Rostock University Medical Center, Universit\u00e4tsmedizin Rostock  Rostock 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