{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T13:43:12Z","timestamp":1782394992198,"version":"3.54.5"},"reference-count":199,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T00:00:00Z","timestamp":1736812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anim Models and Exp Med"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The increasing incidence of neurodegenerative diseases (NDs) and the constraints of existing treatment methods have spurred a keen interest in investigating alternative therapies. Medicinal plants, renowned for their long\u2010standing use in traditional medicine, offer a hopeful avenue for discovering new neuroprotective agents. This study emphasizes the potential neuroprotective characteristics of edible fruit plants in Bangladesh, specifically focusing on their traditional folk medicine uses for neurological disorders. This study provides an in\u2010depth overview of the different types of edible fruit trees in Bangladesh and their phytochemicals, including flavonoids, terpenoids, and phenolic acids. This work examines the scientific data supporting the neuroprotective properties of bioactive chemicals from plants. It further explores the mechanisms by which these compounds work to counteract oxidative stress, decrease inflammation, and stimulate neurogenesis. Moreover, the study investigates toxicological characteristics and bioactive components of some fruits, emphasizing the importance of further investigation to measure their safety profile comprehensively. This thorough study highlights the potential benefits of Bangladesh's edible fruit trees as a rich source of neuroprotective chemicals. It also shows that additional research might lead to novel approaches for improving brain functioning and preventing NDs.<\/jats:p>","DOI":"10.1002\/ame2.12522","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T16:08:55Z","timestamp":1736870935000},"page":"239-265","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Exploring the neuroprotective benefits of phytochemicals extracted from indigenous edible fruits in Bangladesh"],"prefix":"10.1002","volume":"8","author":[{"given":"Sumon","family":"Roy","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Faculty of Pharmacy University of Dhaka  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sajib Chandra","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Pharmacy University of Dhaka  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrukh","family":"Zehravi","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, College of Dentistry &amp; Pharmacy Buraydah Private Colleges  Buraydah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherouk Hussein","family":"Sweilam","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, College of Pharmacy Prince Sattam Bin Abdulaziz University  Al\u2010Kharj Saudi Arabia"},{"name":"Department of Pharmacognosy, Faculty of Pharmacy Egyptian Russian University  Badr City Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajib","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Pharmacy University of Dhaka  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mylsamy","family":"Palanisamy","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim Pharmaceuticals Inc.  Powell Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkata Lakshamana Sagar","family":"Dantinapalli","sequence":"additional","affiliation":[{"name":"Veranova  Davens Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selvaraja","family":"Elumalai","sequence":"additional","affiliation":[{"name":"Granules Pharmaceuticals Inc.  Chantilly Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeetendra Kumar","family":"Gupta","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Research GLA University  Mathura Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Ali","family":"Alshehri","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science University of Tabuk  Tabuk Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Asiri","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Sciences, College of Applied Medical Science King Khalid University  Abha Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irfan","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Sciences, College of Applied Medical Science King Khalid University  Abha Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed H.","family":"Nafady","sequence":"additional","affiliation":[{"name":"Department of Radiology and Medical Imaging Technology, Faculty of Applied Health Science Technology Misr University for Science and Technology  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3188-2272","authenticated-orcid":false,"given":"Talha Bin","family":"Emran","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Health and Life Sciences Daffodil International University  Dhaka 1207 Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,14]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40898-017-0004-7"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.5530\/pj.2015.7.1"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30411-9"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30499-X"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(04)90064-1"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05291"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20624"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0705036104"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0040059915619928"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159x16666180911124605"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.74472"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7591951"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.04.020"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2005.10.005"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-7847.99898"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1A092"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.3329\/jbs.v27i0.44672"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.9734\/ejmp\/2016\/19012"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/679810"},{"key":"e_1_2_14_21_1","first-page":"1","article-title":"The use of plants in traditional health care practice: an ethnomedicinal survey at Mymensingh Sadar and Shambhuganj area in Mymensingh district of Bangladesh","volume":"8","author":"Saha TK","year":"2023","journal-title":"Int J Innov Sci Res Technol"},{"issue":"4","key":"e_1_2_14_22_1","first-page":"862","article-title":"A survey of medicinal plants in two areas of Dinajpur district, Bangladesh including plants which can be used as functional foods","volume":"3","author":"Rahmatullah M","year":"2009","journal-title":"Am J Sustain Agric"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-4269-10-19"},{"issue":"5","key":"e_1_2_14_24_1","first-page":"319","article-title":"Ethnomedicinal usage of plants and animals by folk medicinal practitioners of three villages in Chuadanga and Jhenaidah districts, Bangladesh","volume":"7","author":"Khatun A","year":"2013","journal-title":"Am J Sustain Agric"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.4172\/2329-6836.1000334"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13002-015-0033-3"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/database\/bav075.H"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(99)00179-3"},{"issue":"3","key":"e_1_2_14_29_1","first-page":"363","article-title":"A survey of medicinal and functional food plants used by the folk medicinal practitioners of three villages in Sreepur Upazilla, Magura district, Bangladesh","volume":"4","author":"Rahmatullah M","year":"2010","journal-title":"Am J Sustain Agric"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.5455\/jice.20170719010256"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijnpnd.ijnpnd"},{"issue":"5","key":"e_1_2_14_32_1","first-page":"28","article-title":"Medicinal uses of Punica granatum and its health benefits","volume":"1","author":"Bhowmik D","year":"2013","journal-title":"J Pharmacogn Phytochem"},{"issue":"2","key":"e_1_2_14_33_1","first-page":"121","article-title":"Medicinal uses & pharmacological activity of Tamarindus indica","volume":"5","author":"Zohrameena S","year":"2017","journal-title":"World J Pharm Sci"},{"issue":"2","key":"e_1_2_14_34_1","first-page":"67","article-title":"American\u2010Eurasian Journal of sustainable agriculture","volume":"8","author":"At C","year":"2014","journal-title":"Am J Sustain Agric"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1112209109"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.17348\/era.8.0.195-218"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.3329\/bjpt.v26i1.41926"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.4172\/2327-5162.1000210"},{"issue":"1","key":"e_1_2_14_40_1","first-page":"21","article-title":"Traditional medicinal plants used in the treatment of important human diseases of Joypurhat District, Bangladesh study area Ethno\u2010botanical survey","volume":"2","author":"Rahman AHMM","year":"2015","journal-title":"J Biol Pharm Chem Res"},{"issue":"7","key":"e_1_2_14_41_1","first-page":"54","article-title":"Averrhoa Carambola: an updated review","volume":"2","author":"Chakraborty P","year":"2013","journal-title":"Int J Pharma Res Rev"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.5829\/idosi.gjp.2014.8.1.81223"},{"issue":"8","key":"e_1_2_14_43_1","first-page":"1212","article-title":"Herbal medicine: Syzygium cumini: A review","volume":"2","author":"Jadhav VM","year":"2009","journal-title":"J Pharm Res"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2011.608174"},{"issue":"1","key":"e_1_2_14_45_1","first-page":"13","article-title":"Efficacy of unripe Musa Sapientum entire fruit on neuromuscular power and olfactory muscle Creatine kinase","volume":"1","author":"Agama A","year":"2022","journal-title":"AJAMS"},{"issue":"3","key":"e_1_2_14_46_1","first-page":"989","article-title":"Banana fruit pulp and peel involved in antianxiety and antidepressant effects while invigorate memory performance in male mice: possible role of potential antioxidants","volume":"30","author":"Samad N","year":"2017","journal-title":"Pak J Pharm Sci"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.13040\/IJPSR.0975-8232.10(6).2911-16"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1590\/1414-431X20154773"},{"issue":"1","key":"e_1_2_14_49_1","first-page":"181","article-title":"Methanol extract of Artocarpus heterophyllus attenuates pentylenetetrazole induced anxiety like behaviours in mice","volume":"5","author":"Sharma K","year":"2017","journal-title":"J Med Plants Stud"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1177\/00368504211011866"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-812491-8.00048-5"},{"issue":"3","key":"e_1_2_14_52_1","first-page":"1095","article-title":"Health and medicinal properties of lemon (citrus Limonum)","volume":"1","author":"Mohanapriya M","year":"2013","journal-title":"Int J Ayurvedic Herb Med"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9070609"},{"issue":"9","key":"e_1_2_14_54_1","first-page":"2617","article-title":"Nutritional bioactive compounds and health benefits of fresh and processed cucumber (Cucumis sativus L.) value\u2010added products from cassava view project antibiotic susceptibility testing view project nutritional bioactive compounds and health benefits of F","volume":"3","author":"Uthpala TGG","year":"2020","journal-title":"Sumerianz J Biotechnol"},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5644"},{"key":"e_1_2_14_56_1","first-page":"8","article-title":"Pharmacological potentials of Citrus paradisi\u2010an overview","volume":"1","author":"Gupta V","year":"2017","journal-title":"Medicine"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.53730\/ijhs.v6ns4.10163"},{"key":"e_1_2_14_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2020.104939"},{"key":"e_1_2_14_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2010.05.005"},{"key":"e_1_2_14_60_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40816-018-0083-x"},{"issue":"1","key":"e_1_2_14_61_1","first-page":"58","article-title":"Medicinal properties of Cucumis melo Linn","volume":"2","author":"Asif HM","year":"2014","journal-title":"J Pharm Pharm Sci"},{"key":"e_1_2_14_62_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.0c00824"},{"key":"e_1_2_14_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.1998.tb01670.x"},{"key":"e_1_2_14_64_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28145415"},{"key":"e_1_2_14_65_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9050477"},{"key":"e_1_2_14_66_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14040819"},{"key":"e_1_2_14_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-64056-7.00013-1"},{"key":"e_1_2_14_68_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf026182t"},{"key":"e_1_2_14_69_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom10020221"},{"key":"e_1_2_14_70_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13092940"},{"key":"e_1_2_14_71_1","doi-asserted-by":"publisher","DOI":"10.22271\/journalofsport.2021.v6.i1e.2236"},{"key":"e_1_2_14_72_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22115514"},{"key":"e_1_2_14_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2006.06.025"},{"key":"e_1_2_14_74_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389557523666230214101821"},{"issue":"8","key":"e_1_2_14_75_1","first-page":"4013","article-title":"Flavonoids: chemistry, biochemistry and antioxidant activity","volume":"5","author":"Alzand KI","year":"2012","journal-title":"J Pharm Res"},{"key":"e_1_2_14_76_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9020099"},{"key":"e_1_2_14_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2012.08.002"},{"key":"e_1_2_14_78_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.922232"},{"issue":"1","key":"e_1_2_14_79_1","first-page":"47","article-title":"Plants and secondary metabolites (tannins): a review","volume":"1","author":"Hassanpour S","year":"2011","journal-title":"Int J for Soil Eros"},{"key":"e_1_2_14_80_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24122213"},{"key":"e_1_2_14_81_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570193x1103140915111559"},{"key":"e_1_2_14_82_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules17033524"},{"key":"e_1_2_14_83_1","doi-asserted-by":"publisher","DOI":"10.63019\/ajb.v1i2.467"},{"issue":"2","key":"e_1_2_14_84_1","first-page":"1","article-title":"A review on the alkaloids an important therapeutic compound from plants","volume":"3","author":"Roy A","year":"2017","journal-title":"Int J Plant Biotechnol"},{"key":"e_1_2_14_85_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26030728"},{"key":"e_1_2_14_86_1","first-page":"1","article-title":"Alkaloids as new leads for neurodegenerative diseases","volume":"11","author":"Al\u2010Mamoori F","year":"2023","journal-title":"IntechOpen"},{"key":"e_1_2_14_87_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2019.1672658"},{"key":"e_1_2_14_88_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.0c04739"},{"key":"e_1_2_14_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-022-01631-6"},{"key":"e_1_2_14_90_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043754"},{"issue":"7","key":"e_1_2_14_91_1","first-page":"1","article-title":"The situation of Alzheimer's disease in Bangladesh: facilities, expertise, and awareness among general people","volume":"8","author":"Roy N","year":"2020","journal-title":"J Neurol Disord"},{"key":"e_1_2_14_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2009.11.006"},{"key":"e_1_2_14_93_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/8964849"},{"key":"e_1_2_14_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2017.07.056"},{"key":"e_1_2_14_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fshw.2014.02.001"},{"key":"e_1_2_14_96_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28104121"},{"key":"e_1_2_14_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metop.2021.100077"},{"key":"e_1_2_14_98_1","doi-asserted-by":"publisher","DOI":"10.4103\/1735-5362.207198"},{"key":"e_1_2_14_99_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11050816"},{"key":"e_1_2_14_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.114570"},{"key":"e_1_2_14_101_1","doi-asserted-by":"publisher","DOI":"10.3390\/life13040999"},{"key":"e_1_2_14_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111609"},{"key":"e_1_2_14_103_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-012-0799-9"},{"key":"e_1_2_14_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.03.009"},{"key":"e_1_2_14_105_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X18500192"},{"key":"e_1_2_14_106_1","doi-asserted-by":"publisher","DOI":"10.9734\/bjmmr\/2014\/7206"},{"key":"e_1_2_14_107_1","doi-asserted-by":"publisher","DOI":"10.1080\/22311866.2014.921121"},{"key":"e_1_2_14_108_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867323666160106150821"},{"key":"e_1_2_14_109_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.2c03291"},{"key":"e_1_2_14_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2021.129721"},{"key":"e_1_2_14_111_1","doi-asserted-by":"publisher","DOI":"10.3390\/jfb14010050"},{"key":"e_1_2_14_112_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/8741669"},{"key":"e_1_2_14_113_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23123283"},{"key":"e_1_2_14_114_1","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2010.541923"},{"key":"e_1_2_14_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2015.09.031"},{"issue":"6","key":"e_1_2_14_116_1","first-page":"1837","article-title":"Memory boosting effect of Citrus limon, pomegranate and their combinations","volume":"27","author":"Riaz A","year":"2014","journal-title":"Pak J Pharm Sci"},{"key":"e_1_2_14_117_1","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/431068"},{"key":"e_1_2_14_118_1","doi-asserted-by":"publisher","DOI":"10.1080\/87559129.2021.1906697"},{"key":"e_1_2_14_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2007.12.017"},{"key":"e_1_2_14_120_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2010.77"},{"key":"e_1_2_14_121_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13765-012-2110-9"},{"key":"e_1_2_14_122_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-101287"},{"key":"e_1_2_14_123_1","doi-asserted-by":"publisher","DOI":"10.4062\/biomolther.2014.068"},{"key":"e_1_2_14_124_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21010202"},{"key":"e_1_2_14_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2014.06.004"},{"key":"e_1_2_14_126_1","doi-asserted-by":"publisher","DOI":"10.1080\/1028415X.2017.1360558"},{"key":"e_1_2_14_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.01.025"},{"key":"e_1_2_14_128_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871527316666170328113309"},{"key":"e_1_2_14_129_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-015-1571-8"},{"key":"e_1_2_14_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2010.06.024"},{"key":"e_1_2_14_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2015.09.002"},{"key":"e_1_2_14_132_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjp.2008.356"},{"key":"e_1_2_14_133_1","doi-asserted-by":"publisher","DOI":"10.5530\/ijpi.2020.2.37"},{"key":"e_1_2_14_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-811518-3\/00007-7"},{"key":"e_1_2_14_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2010.04.005"},{"key":"e_1_2_14_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2014.05.013"},{"key":"e_1_2_14_137_1","doi-asserted-by":"publisher","DOI":"10.18926\/AMO\/56243"},{"key":"e_1_2_14_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.07.145"},{"key":"e_1_2_14_139_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13197-013-0993-z"},{"key":"e_1_2_14_140_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.107.038984"},{"key":"e_1_2_14_141_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-015-1627-9"},{"key":"e_1_2_14_142_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-014-9948-0"},{"key":"e_1_2_14_143_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.699899"},{"key":"e_1_2_14_144_1","doi-asserted-by":"publisher","DOI":"10.1179\/1476830514Y.0000000155"},{"key":"e_1_2_14_145_1","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/4035987"},{"key":"e_1_2_14_146_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9070659"},{"key":"e_1_2_14_147_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-014-0172-4"},{"key":"e_1_2_14_148_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2013.110"},{"key":"e_1_2_14_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.02.052"},{"key":"e_1_2_14_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111511"},{"key":"e_1_2_14_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2019.03.001"},{"key":"e_1_2_14_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00218-X"},{"key":"e_1_2_14_153_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.049727"},{"key":"e_1_2_14_154_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389450121999201013155202"},{"key":"e_1_2_14_155_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-019-00038-6"},{"key":"e_1_2_14_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2020.03.003"},{"key":"e_1_2_14_157_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.01059"},{"key":"e_1_2_14_158_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.01555"},{"key":"e_1_2_14_159_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2018.24"},{"key":"e_1_2_14_160_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-023-01700-8"},{"key":"e_1_2_14_161_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15020306"},{"key":"e_1_2_14_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jafr.2020.100081"},{"key":"e_1_2_14_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-817780-8.00016-5"},{"key":"e_1_2_14_164_1","doi-asserted-by":"publisher","DOI":"10.9790\/3013-068015275"},{"issue":"3","key":"e_1_2_14_165_1","first-page":"175","article-title":"Multiple sclerosis review","volume":"37","author":"Goldenberg MM","year":"2012","journal-title":"J Clin Pharm Ther"},{"key":"e_1_2_14_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2020.05.049"},{"key":"e_1_2_14_167_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2022.2131729"},{"key":"e_1_2_14_168_1","doi-asserted-by":"publisher","DOI":"10.22037\/ijpr.2019.112181.13582"},{"key":"e_1_2_14_169_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2000208117"},{"key":"e_1_2_14_170_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24054334"},{"key":"e_1_2_14_171_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10071-23192"},{"key":"e_1_2_14_172_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.309278"},{"key":"e_1_2_14_173_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9060598"},{"key":"e_1_2_14_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2013.10.009"},{"key":"e_1_2_14_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2016.02.011"},{"key":"e_1_2_14_176_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.12775"},{"key":"e_1_2_14_177_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-813278-4.00002-6"},{"key":"e_1_2_14_178_1","doi-asserted-by":"publisher","DOI":"10.31083\/j.jin2101014"},{"issue":"11","key":"e_1_2_14_179_1","first-page":"175","article-title":"Efficacy of morin as a potential therapeutic phytocomponent: insights into the mechanism of action","volume":"6","author":"Choudhury A","year":"2017","journal-title":"Int J Med Res Heal Sci"},{"issue":"2","key":"e_1_2_14_180_1","first-page":"99","article-title":"Therapeutic potential of herbal drugs in cerebral ischemia","volume":"54","author":"Gupta YK","year":"2010","journal-title":"Indian J Physiol Pharmacol"},{"key":"e_1_2_14_181_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5471347"},{"key":"e_1_2_14_182_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.20633"},{"key":"e_1_2_14_183_1","doi-asserted-by":"publisher","DOI":"10.31887\/dcns.2017.19.2\/fthibaut"},{"key":"e_1_2_14_184_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-014-9616-2"},{"key":"e_1_2_14_185_1","doi-asserted-by":"publisher","DOI":"10.1080\/02648725.2022.2122296"},{"key":"e_1_2_14_186_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20061305"},{"key":"e_1_2_14_187_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X1304150831123535"},{"key":"e_1_2_14_188_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.11096su1c.01"},{"key":"e_1_2_14_189_1","doi-asserted-by":"publisher","DOI":"10.2753\/IMH0020-7411420403"},{"key":"e_1_2_14_190_1","doi-asserted-by":"publisher","DOI":"10.1093\/fqsafe\/fyy019"},{"key":"e_1_2_14_191_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11418-016-0970-8"},{"key":"e_1_2_14_192_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000002945"},{"key":"e_1_2_14_193_1","doi-asserted-by":"publisher","DOI":"10.17812\/blj2015.32.18"},{"key":"e_1_2_14_194_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2020.104785"},{"key":"e_1_2_14_195_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2003.09.001"},{"key":"e_1_2_14_196_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2221-6189(15)30023-8"},{"key":"e_1_2_14_197_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2017.04.002"},{"issue":"5","key":"e_1_2_14_198_1","first-page":"498","article-title":"In vitro antidiarrhoeal activity and toxicity profile of Aegle marmelos Correa ex Roxb. Dried fruit pulp","volume":"8","author":"Joshi PV","year":"2009","journal-title":"Nat Prod Radiance"},{"issue":"1","key":"e_1_2_14_199_1","first-page":"48","article-title":"Acute and chronic oral toxicity of standardized water extract from the fruit of Phyllanthus emblica Linn","volume":"3","author":"Jaijoy K","year":"2010","journal-title":"Int J Appl Res Nat Prod"},{"key":"e_1_2_14_200_1","doi-asserted-by":"publisher","DOI":"10.1080\/01480540802432551"}],"container-title":["Animal Models and Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ame2.12522","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T09:36:46Z","timestamp":1741772206000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ame2.12522"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,14]]},"references-count":199,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1002\/ame2.12522"],"URL":"https:\/\/doi.org\/10.1002\/ame2.12522","archive":["Portico"],"relation":{},"ISSN":["2576-2095","2576-2095"],"issn-type":[{"value":"2576-2095","type":"print"},{"value":"2576-2095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,14]]},"assertion":[{"value":"2024-09-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}