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In most studies, oxidative stress has been identified as the primary pathophysiological mechanism underlying the harmful effects of electromagnetic waves. This paper aims to provide a holistic review of the protective effects of melatonin against cell phone\u2010induced electromagnetic waves on various organs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study is a systematic review of articles chosen by searching Google Scholar, PubMed, Embase, Scopus, Web of Science, and Science Direct using the keywords \u2018melatonin\u2019, \u2018cell phone radiation\u2019, and \u2018animal model\u2019. The search focused on articles written in English, which were reviewed and evaluated. The PRISMA process was used to review the articles chosen for the study, and the JBI checklist was used to check the quality of the reviewed articles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the final review of 11 valid quality\u2010checked articles, the effects of melatonin in the intervention group, the effects of electromagnetic waves in the case group, and the amount of melatonin in the chosen organ, i.e. brain, skin, eyes, testis and the kidney were thoroughly examined. The review showed that electromagnetic waves increase cellular anti\u2010oxidative activity in different tissues such as the brain, the skin, the eyes, the testis, and the kidneys. Melatonin can considerably augment the anti\u2010oxidative system of cells and protect tissues; these measurements were significantly increased in control groups. Electromagnetic waves can induce tissue atrophy and cell death in various organs including the brain and the skin and this effect was highly decreased by melatonin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our review confirms that melatonin effectively protects the organs of animal models against electromagnetic waves. In light of this conclusion and the current world\u2010wide use of melatonin, future studies should advance to the stages of human clinical trials. We also recommend that more research in the field of melatonin physiology is conducted in order to protect exposed cells from dying and that melatonin should be considered as a pharmaceutical option for treating the complications resulting from electromagnetic waves in humans.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ame2.12552","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T18:51:56Z","timestamp":1740595916000},"page":"629-637","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The protective effects of melatonin against electromagnetic waves of cell phones in animal models: A systematic review"],"prefix":"10.1002","volume":"8","author":[{"given":"Mohammad","family":"Amiri","sequence":"first","affiliation":[{"name":"Sleep Disorders Research Center Kermanshah University of Medical Sciences  Kermanshah Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Habibolah","family":"Khazaie","sequence":"additional","affiliation":[{"name":"Sleep Disorders Research Center Kermanshah University of Medical Sciences  Kermanshah Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5722-8300","authenticated-orcid":false,"given":"Masoud","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"Research Center for Social Determinants of Health Jahrom University of Medical Sciences  Jahrom Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,24]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21061915"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1515\/reveh-2017-0014"},{"key":"e_1_2_13_4_1","first-page":"273","article-title":"Provocation study using heart rate variability shows microwave radiation from 2.4 GHz cordless phone affects autonomic nervous system","volume":"5","author":"Havas M","year":"2010","journal-title":"Eur J Oncol"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2020.109445"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2011.11.008"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2010.05.008"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-9-77"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.116.196154"},{"issue":"4","key":"e_1_2_13_10_1","first-page":"1","article-title":"The effects on cells mobility due to exposure to EMF radiation","volume":"2","author":"Aly AA","year":"2011","journal-title":"Adv Comput"},{"issue":"7","key":"e_1_2_13_11_1","first-page":"890","article-title":"Melatonin as a possible natural safener in crops","volume":"11","author":"Giraldo Acosta M","year":"2022","journal-title":"Plants (Basel)"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.140.10.7074"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(03)01008-2"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0303-7207(91)90087-9"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/10409230903044914"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2010.00748.x"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2010.00752.x"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1385\/ENDO:27:2:189"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2009.00729.x"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2010.00767.x"},{"key":"e_1_2_13_21_1","first-page":"57","article-title":"Melatonin: a potent endogenous hydroxyl radical scavenger","volume":"1","author":"Tan D\u2010X","year":"1993","journal-title":"Endocr J"},{"key":"e_1_2_13_22_1","unstructured":"Scopus Citation Index hwsc. 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