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This paper discusses a large series of minimally invasive LMEP recordings in 46 female Lewis rats, implanted with a custom\u2010made VNS electrode around the left cervical vagus nerve. After a 3\u2010week recovery, LMEPs were recorded twice in each animal, with swapping the anode and cathode positions of the VNS electrode (polarity inversion). A VNS\u2010induced LMEP was identified as the initial negative peak wave post\u2010stimulation artifact, consistently recorded in all sweeps at a given stimulation output current. Latency was defined as the time from stimulation onset to this negative peak, and stimulation threshold as the lowest current showing a clear and reproducible LMEP. An LMEP response was shown by 37\/46 animals (80.4%), with stimulation intensity threshold of 0.37\u2009\u00b1\u20090.27\u2009mA and latency of 2.39\u2009\u00b1\u20090.45\u2009ms. Administering the cathodic pulse phase first at the caudal electrode contact resulted in the shortest LMEP latencies (MWU: <jats:italic>p<\/jats:italic>\u2009=\u20090.049. 2.36\u2009\u00b1\u20090.43\u2009ms vs. 2.41\u2009\u00b1\u20090.47\u2009ms). Minimally invasive LMEP recording provides a feasible and reliable means for checking electrode functioning and correct implantation.<\/jats:p>","DOI":"10.1002\/ame2.12555","type":"journal-article","created":{"date-parts":[[2025,2,9]],"date-time":"2025-02-09T02:39:55Z","timestamp":1739068795000},"page":"750-757","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Use of laryngeal muscle evoked potential recording for experimental vagus nerve stimulation"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3893-5608","authenticated-orcid":false,"given":"Helen","family":"Bachmann","sequence":"first","affiliation":[{"name":"4Brain, Department of Neurology, Ghent University Hospital Ghent University  Gent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robrecht","family":"Raedt","sequence":"additional","affiliation":[{"name":"4Brain, Department of Neurology, Ghent 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