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Selecting suitable animals for preclinical models is of great significance in research on the prevention, early screening, and effective treatments of glaucoma. Rabbit eyeballs possess similar vascularity and aqueous humor outflow pathways to those of humans. Thus, they are among the earliest in\u00a0vivo models used in glaucoma research. Over the years, rabbit models have made substantial contributions to understanding glaucomatous pathophysiology, surgical adaptations, biomedical device development, and drug development for reducing IOP, protecting RGCs, and inhibiting fibrosis. Compared to other animals, rabbits fit better with surgical operations and cost less. This review summarizes the merits and demerits of different ways to produce glaucomatous rabbit models, such as intracameral injection, vortex vein obstruction, Trendelenburg position, laser photo\u2010coagulation, glucocorticoid induction, limbal buckling induction, retinal ischemia\u2013reperfusion models, and spontaneous models. We analyzed their mechanisms in the hope of providing more references for experimental design and promoting the understanding of glaucoma treatment strategies.<\/jats:p>","DOI":"10.1002\/ame2.12565","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T11:59:41Z","timestamp":1738843181000},"page":"429-440","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Glaucoma animal models in rabbits: State of the art and perspectives\u2014A review"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7154-1416","authenticated-orcid":false,"given":"Rong","family":"Hu","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Hunan University of Chinese Medicine  Changsha China"},{"name":"Hunan University of Chinese Medicine  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Wu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Hunan University of Chinese Medicine  Changsha China"},{"name":"Hunan University of Chinese Medicine  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Shi","sequence":"additional","affiliation":[{"name":"Hunan University of Chinese Medicine  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Yu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Hunan University of Chinese Medicine  Changsha China"},{"name":"Hunan University of Chinese Medicine  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010lei","family":"Yao","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Hunan University of Chinese Medicine  Changsha China"},{"name":"Hunan University of Chinese Medicine  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)01289-8"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31469-1"},{"issue":"12","key":"e_1_2_10_4_1","first-page":"1850","article-title":"Application of glaucoma animal model in glaucoma study","volume":"41","author":"Shuo SONG","year":"2021","journal-title":"Nat Sci"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-925X-13-30"},{"key":"e_1_2_10_6_1","first-page":"1","article-title":"Assessing ocular toxicology in laboratory animals || comparative ocular anatomy in commonly used laboratory animals","volume":"1","author":"Weir AB","year":"2013","journal-title":"Mol Integr Toxicol"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.9.3.20"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.15027"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2019.10.002"},{"issue":"2","key":"e_1_2_10_10_1","first-page":"126","article-title":"Chronic experimental glaucoma in primates. 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