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These viruses can infect humans and other vertebrates, primarily targeting the skin, mucous membranes, and neural tissues, thereby significantly impacting the health of both humans and animals. Animal models are crucial for studying virus pathogenesis, vaccine development, and drug testing. Despite several vaccine candidates being in preclinical and clinical stages, no vaccines are current available to prevent lifelong infections caused by these human herpesviruses, except for varicella\u2010zoster virus (VZV) vaccine. However, the strict host tropism of herpesviruses and other limitations mean that no single animal model can fully replicate all key features of human herpesvirus\u2010associated diseases. This makes it challenging to evaluate vaccines and antivirals against human herpesvirus comprehensively. Herein, we summarize the current animal models used to study the human herpesviruses including \u03b1\u2010herpesviruses (herpes simplex virus type 1(HSV\u20101), HSV\u20102, VZV), \u03b2\u2010herpesviruses (human cytomegalovirus (HCMV), \u03b3\u2010herpesviruses (Epstein\u2013Barr virus (EBV)) and Kaposi's sarcoma herpesvirus (KSHV)). By providing concise information and detailed analysis of the potential, limitations and applications of various models, such as non\u2010human primates, mice, rabbits, guinea pigs, and tree shrews, this summary aims to help researchers efficiently select the most appropriate animal model, offering practical guidance for studying human herpesvirus.<\/jats:p>","DOI":"10.1002\/ame2.12575","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T01:43:36Z","timestamp":1739238216000},"page":"615-628","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Animal models of human herpesvirus infection"],"prefix":"10.1002","volume":"8","author":[{"given":"Ziqing","family":"Jia","sequence":"first","affiliation":[{"name":"NHC Key Laboratory of Human Disease Comparative Medicine Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing 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