{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:24:05Z","timestamp":1792121045893,"version":"4.4.0"},"reference-count":49,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T00:00:00Z","timestamp":1746403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T00:00:00Z","timestamp":1746403200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anim Models and Exp Med"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Diabetes, a metabolic disease marked by endocrine dysfunctions, significantly impacts oxidative stress pathways. This study explores the protective effects of lemongrass extract (LE), citral, and lemongrass extract\u2010synthesized silver nanoparticles (LE\u2010AgNP) against hyperglycemia\u2010induced oxidative stress by modulating the Nrf2 pathway, which is crucial for antioxidant responses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Various techniques characterized the nanoparticles, including ultraviolet\u2013visible spectroscopy, dynamic light scattering, zeta potential analysis, Fourier\u2010transform infrared spectroscopy, scanning electron microscopy and transmission electron microscopy. Seventy rats, divided into seven groups, were used for in\u00a0vivo experiments. Type 2 diabetes was induced using streptozotocin (65\u2009mg\/kg) and nicotinamide (90\u2009mg\/kg). After six weeks, biochemical parameters such as total antioxidant capacity, malondialdehyde, Nrf2, and Nrf2 miRNA were evaluated in pancreas tissue and blood serum, along with serum blood glucose levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>LE\u2010AgNP significantly improved weight gain, reduced food and water intake, and lowered blood glucose levels in diabetic rats. LE and citral did not significantly alter these parameters but prevented the decline in Nrf2 gene expression. LE\u2010AgNP showed a significant increase in Nrf2 gene expression compared to the diabetic control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study highlights the potential of LE, citral, and especially LE\u2010AgNP in mitigating oxidative stress induced by diabetes. LE\u2010AgNP demonstrated superior therapeutic benefits, including improved oxidative stress conditions and hypoglycemic effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ame2.70017","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T02:29:12Z","timestamp":1746498552000},"page":"2128-2138","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Comparison of the effects of metformin, citral,\n                    <i>Cymbopogon citratus<\/i>\n                    extract and silver nanoparticles of\n                    <i>Cymbopogon citratus<\/i>\n                    extract on oxidative stress indices and Nrf2 levels in experimental type 2 diabetes in rats"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1058-8778","authenticated-orcid":false,"given":"Milad","family":"Faraji","sequence":"first","affiliation":[{"name":"Department of Basic Sciences, School of Veterinary Medicine Shiraz University  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Foad","family":"Noorbakhsh","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences, School of Veterinary Medicine Shiraz University  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2939-1776","authenticated-orcid":false,"given":"Nasrin","family":"Kazemipour","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences, School of Veterinary Medicine Shiraz University  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Nazifi","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, School of Veterinary Medicine Shiraz University  Shiraz 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