{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T02:06:34Z","timestamp":1780452394005,"version":"3.54.1"},"reference-count":59,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005999","name":"Bangladesh Council of Scientific and Industrial Research","doi-asserted-by":"publisher","award":["39.02.0000.011.14.157.2022\/172"],"award-info":[{"award-number":["39.02.0000.011.14.157.2022\/172"]}],"id":[{"id":"10.13039\/501100005999","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anim Models and Exp Med"],"published-print":{"date-parts":[[2025,7]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Colocasia esculenta<\/jats:italic> (L.) Schott, known as the taro vegetable, possesses various beneficial effects and is traditionally used in folk medicine. This study explores the ameliorative antioxidant and hepatoprotective effect of a methanolic extract of the C. esculenta<\/jats:italic> flower (ME\u2010CEF) against oxidative damage and hepatotoxicity in mice.<\/jats:p><\/jats:sec>Methods<\/jats:title>The antioxidant efficacy of ME\u2010CEF was assessed using 2,2\u2032\u2010azino\u2010bis\u2010(3\u2010ethylbenzothiazoline\u20106\u2010sulfonic) (ABTS) and 2,2\u2010diphenyl\u20101\u2010picrylhydrazyl (DPPH) scavenging assay. The hepatoprotective effect was investigated by an assessment of liver injury indicators (amino transferase [ALT], aspartate amino transferase [AST], alkaline phosphatase [ALP], bilirubin, creatinine) and normalizing lipid profiles (cholesterol [CHO], triglyceride [TG], high\u2010density lipoprotein [HDL], and low\u2010density lipoprotein [LDL]) along with histopathological study and antioxidant enzymes (CAT). A phytochemical analysis, both qualitative and quantitative, was conducted, including gas chromatography\u2010tandem mass spectrometry (GC\u2013MS\/MS) analysis and an in silico molecular docking study.<\/jats:p><\/jats:sec>Results<\/jats:title>The Result Showed that ME<\/jats:styled-content>\u2010CEF<\/jats:styled-content> Possesses Moderate ABTS<\/jats:styled-content> and DPPH<\/jats:styled-content> Scavenging Activity with IC50<\/jats:sub><\/jats:styled-content> Values of 117.18 and 160.41\u2009\u03bcg\/mL<\/jats:styled-content>. As Illustrated by Reducing Liver Enzymes (ALT<\/jats:styled-content>, AST<\/jats:styled-content>, ALP<\/jats:styled-content>, Bilirubin, Creatinine) and Lipid Profile (CHO<\/jats:styled-content>, TG<\/jats:styled-content>, LDL<\/jats:styled-content>) and Raising HDL<\/jats:styled-content> Levels (p<\/jats:italic>\u2009<\u20090.01), ME<\/jats:styled-content>\u2010CEF<\/jats:styled-content> Dose Dependently Mitigated CCl4<\/jats:sub><\/jats:styled-content>\u2010Induced Acute Liver Injury. Furthermore, ME<\/jats:styled-content>\u2010CEF<\/jats:styled-content> Blocked Hepatic Oxidative Stress by Boosting Antioxidant Enzymes (CAT<\/jats:styled-content>) and Preventing Liver Tissue Damage and Apoptosis. In Silico Investigations Also Showed a Promising Binding Affinity with Tumor Necrosis Factor \u03b1 (TNF<\/jats:styled-content>\u2010\u03b1), Interleukin 6 (IL<\/jats:styled-content>\u20106), PRAP<\/jats:styled-content>\u20101, and Xanthin Oxidoreductase, which Displayed Antioxidant and Hepatoprotective Candidacy while Notable Safety and Efficacy Profile Was Also Documented through ADME<\/jats:styled-content>\/T Studies. Histopathological Analysis Showed Reduced Hepatocellular Necrosis and Vascular Congestion in Silymarin and Extract Groups.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Based on these results, our findings strongly recommend the medicinal use of the plant, highlighting its antioxidant and hepatoprotective potentials.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ame2.70031","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T02:14:21Z","timestamp":1748484861000},"page":"1166-1185","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A hepatoprotective experiment on taro vegetable (Colocasia esculenta<\/i> (L.) Schott) flower employing animal models by mitigating oxidative stress"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4169-899X","authenticated-orcid":false,"given":"Mahathir","family":"Mohammad","sequence":"first","affiliation":[{"name":"Department of Chemistry Chittagong University of Engineering & Technology Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7271-4219","authenticated-orcid":false,"given":"Fahmida Tasnim","family":"Richi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy University of Dhaka Dhaka Bangladesh"},{"name":"Department of Pharmacy University of Asia Pacific Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabiul","family":"Hossain","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Science and Technology Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md.","family":"Arafat","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology University of Science and Technology Chittagong Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pair Ahmed","family":"Jiko","sequence":"additional","affiliation":[{"name":"Department of Chemistry Chittagong University of Engineering & Technology Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7567-4796","authenticated-orcid":false,"given":"Nazim Uddin","family":"Emon","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Science and Engineering International Islamic University Chittagong Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayed Al Hossain","family":"Rabbi","sequence":"additional","affiliation":[{"name":"Department of Chemistry Government City College, Chattogram, National University Chattogram Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tirtha","family":"Khastagir","sequence":"additional","affiliation":[{"name":"Department of Pathology Marine City Medical College Chattogram Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8759-9279","authenticated-orcid":false,"given":"Md. Hemayet","family":"Hossain","sequence":"additional","affiliation":[{"name":"Chemical Research Division, BCSIR Dhaka Laboratories Bangladesh Council of Scientific and Industrial Research (BCSIR) Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1831-2278","authenticated-orcid":false,"given":"Safaet","family":"Alam","sequence":"additional","affiliation":[{"name":"Chemical Research Division, BCSIR Dhaka Laboratories Bangladesh Council of Scientific and Industrial Research (BCSIR) Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,28]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119436812.ch1"},{"issue":"3","key":"e_1_2_12_3_1","first-page":"166","article-title":"Development of phytomedicines for liver diseases","volume":"31","author":"Subramoniam A","year":"1999","journal-title":"Indian J Pharm"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/43.8.1512"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/13813455.2019.1702062"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748233713499600"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms161125942"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2008.07.010"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113840"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10295-015-1723-5"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2008.07.004"},{"issue":"4","key":"e_1_2_12_12_1","first-page":"156","article-title":"Taro (Colocasia esculenta): an overview","volume":"6","author":"Rashmi D","year":"2018","journal-title":"J Med Plants Stud"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-15-7470-2_18"},{"issue":"1","key":"e_1_2_12_14_1","first-page":"10","article-title":"Potential use of dragon fruit and Taro leaves as functional food","volume":"1","author":"Shekade DP","year":"2018","journal-title":"Eur J Eng Sci Technol"},{"issue":"2","key":"e_1_2_12_15_1","first-page":"82","article-title":"In\u2010vitro anthelmintic activity of Colocasia esculenta","volume":"2","author":"Kubde MS","year":"2010","journal-title":"Der Pharm Lett"},{"issue":"4","key":"e_1_2_12_16_1","first-page":"2165","article-title":"Phenolic Profile: Antimicrobial activity and antioxidant capacity of Colocasia esculenta (L.) 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