{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T15:19:42Z","timestamp":1780759182518,"version":"3.54.1"},"reference-count":41,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:00:00Z","timestamp":1750204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anim Models and Exp Med"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There are many forms of anabolic steroids, including stanozolol (Winstrol), which are popular for their muscle\u2010building effects but dangerous to the heart. This present work is aimed at evaluating the pharmacologica impact of allicin, a natural attribute obtained from garlic, on obstructing cardiac injury in rabbits that received stanozolol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty rabbits were divided into three groups: control, stanozolol\u2010treated, and stanozolol plus allicin. Cardiac function was assessed by measuring troponin, creatine kinase (CK), Galectin\u20103, and GDF\u201015. Oxidative stress and antioxidant markers, including malondialdehyde (MDA), glutathione, and catalase, were analyzed. Inflammatory mediators such as C\u2010reactive protein (CRP), interleukin\u20106 (IL\u20106), NF\u2010\u03baB, iNOS, nitric oxide (NO), tumor necrosis factor\u2010alpha (TNF\u2010\u03b1), and interleukin\u20101 beta (IL\u20101\u03b2) were evaluated. Lipid profile parameters, including total cholesterol, low\u2010density lipoprotein (LDL), and high\u2010density lipoprotein (HDL), were measured. Histopathological examination assessed myocardial damage, fibrosis, and collagen deposition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Stanozolol administration significantly increased cardiac damage markers, oxidative stress, and inflammatory mediators while causing dyslipidemia, characterized by elevated LDL and total cholesterol and reduced HDL. Allicin co\u2010administration effectively countered these effects by reducing oxidative stress and inflammation, restoring antioxidant balance, and improving lipid profiles. Histopathological analysis revealed severe myocardial disorganization, necrosis, and fibrosis in the stanozolol group, whereas the allicin\u2010treated group exhibited preserved myocardial structure with reduced collagen deposition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Allicin significantly mitigates stanozolol\u2010induced cardiotoxicity by reducing oxidative stress, inflammation, lipid dysregulation, and myocardial damage, as evidenced by biochemical and histopathological findings. These results suggest that allicin may serve as a potential therapeutic agent to counteract the cardiovascular risks associated with anabolic steroid use.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ame2.70035","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T01:03:18Z","timestamp":1750294998000},"page":"1196-1205","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Protective effects of allicin against stanozolol\u2010induced cardiotoxicity: Physiological and histopathological evidence in a rabbit model"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5767-2522","authenticated-orcid":false,"given":"Mohammed Hayder","family":"Asker","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, College of Pharmacy Mustansiriyah University Baghdad  Baghdad Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noor 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