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Multimodal cardiac assessments, including echocardiography, transmission electron microscopy for myocardial ultrastructural and mitochondrial analysis, and ex\u00a0vivo cardiomyocyte contractility assays, were systematically applied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Metastatic burden triggered CACC characterized by cardiac mass reduction, epicardial fat depletion, interstitial fibrosis, and electrocardiographic abnormalities. Histopathological analysis revealed cardiomyocyte atrophy, myofibrillar disarray, mitochondrial dysfunction, and ubiquitin\u2010mediated Myh6 degradation via MuRF\u20101, accompanied by compensatory Myh7 upregulation. These findings mechanistically link tumor\u2010induced cachexia to cardiac dysfunction through contractile protein remodeling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This work establishes a preclinical framework for targeting ubiquitin pathways to mitigate the morbidity of cancer\u2010related cardiopathy. Our integrated approach delineates a hierarchical progression from subcellular dysfunction to macroscopic cardiac deterioration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ame2.70060","type":"journal-article","created":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T04:15:17Z","timestamp":1752639317000},"page":"1960-1970","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Development of an efficient mice model of cancer\u2010associated cardiac cachexia"],"prefix":"10.1002","volume":"8","author":[{"given":"Shijie","family":"Xiong","sequence":"first","affiliation":[{"name":"Guangdong Engineering &amp; Technology Research Center for Disease\u2010Model Animals, Laboratory Animal Center Sun Yat\u2010Sen University  Guangzhou Guangdong China"},{"name":"Department of Biochemistry, Zhongshan School of Medicine Sun Yat\u2010Sen University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiting","family":"Zheng","sequence":"additional","affiliation":[{"name":"Guangdong Engineering &amp; 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