{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:27:23Z","timestamp":1786976843733,"version":"build-2736575974"},"reference-count":61,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:00:00Z","timestamp":1760918400000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anim Models and Exp Med"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acute pancreatitis (AP) is a severe inflammation of the pancreas, marked by elevated enzyme levels, cellular inflammation, and necrosis. Recent studies emphasize the critical role of inflammation in AP progression. Tirzepatide, a multi\u2010target agonist of glucagon\u2010like peptide\u20101 (GLP\u20101) and glucose\u2010dependent insulinotropic polypeptide (GIP) receptors, has demonstrated notable anti\u2010inflammatory and metabolic benefits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study explores the therapeutic potential of Tirzepatide in pancreatitis induced by L\u2010arginine in rats, focusing on enzymatic markers, cytokine profiles, oxidative stress, and histological outcomes. Over 27\u2009days, rats were distributed into Control, Tirzepatide, L\u2010Arginine, and L\u2010Arginine + Tirzepatide groups, with the latter receiving L\u2010Arginine to induce pancreatitis followed by Tirzepatide administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>L\u2010Arginine significantly elevated serum amylase, lipase, and inflammatory mediators (IL\u20106, IL\u20104, and IL\u201010), alongside oxidative stress markers and histopathological deterioration. Conversely, the L\u2010Arginine + Tirzepatide group exhibited reduced lipase and IL\u20106 levels, suppressed reactive oxygen species (ROS) generation, and enhanced anti\u2010inflammatory cytokines IL\u20104 and IL\u201010. Histopathological analysis revealed reduced necrosis and tissue damage in the L\u2010Arginine + Tirzepatide group compared to the L\u2010Arginine group, indicating Tirzepatide's possible protective effects. Immunofluorescence studies further demonstrated increased p\u2010Akt expression, supporting the role of Tirzepatide in cellular repair and recovery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings highlight Tirzepatide's ability to mitigate pancreatic damage through antioxidant and anti\u2010inflammatory mechanisms, underscoring its potential as a pharmacological agent for acute pancreatitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ame2.70083","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T04:26:29Z","timestamp":1761020789000},"page":"1876-1887","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Assessing the therapeutic potential of Tirzepatide in modulating inflammatory responses and mitigating acute pancreatitis"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9211-1042","authenticated-orcid":false,"given":"Razan","family":"Alawaji","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology College of Pharmacy, Qassim University  Buraydah Saudi Arabia"},{"name":"King Salman Medical City  Al Madinah Al Munawwarah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed S.","family":"Abdel\u2010Bakky","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology College of Pharmacy, Qassim University  Buraydah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussein M.","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology College of Pharmacy, Qassim University  Buraydah Saudi Arabia"},{"name":"Faculty of Medicine, Department of Biochemistry Al\u2010Azhar University  Assiut Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miad A.","family":"Aljuhani","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology College of Pharmacy, Qassim University  Buraydah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulaziz Arif A.","family":"Alshammari","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology College of Pharmacy, Qassim University  Buraydah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hashim K.","family":"Kamal","sequence":"additional","affiliation":[{"name":"King Salman Medical City  Al Madinah Al Munawwarah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maamoun M. 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