{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T06:06:12Z","timestamp":1764309972724,"version":"3.46.0"},"reference-count":17,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"vor","delay-in-days":34,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000900","name":"California Institute for Regenerative Medicine","doi-asserted-by":"publisher","award":["TRAN3\u201013332"],"award-info":[{"award-number":["TRAN3\u201013332"]}],"id":[{"id":"10.13039\/100000900","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anim Models and Exp Med"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Over 550\u2009000 people in the U.S. require hemodialysis for management of end stage renal disease (ESRD). When anatomy restricts fistula creation, arteriovenous grafts (AVG) are implanted. AVGs have poor primary patency and high risk of infection, highlighting a need for better alternatives. Previous AVG large animal models were limited by high complication rates and short\u2010term follow\u2010up. This study investigates the safety and durability of an ovine bilateral carotid\u2010jugular AVG model. Eight female sheep underwent bilateral carotid\u2010jugular AVG implantation via a single longitudinal incision overlying the trachea. Ringed PTFE grafts were anastomosed in a \u201clazy\u2010S\u201d configuration to provide the laxity needed to prevent avulsion and minimize kinking with neck movement. Post\u2010operatively, sheep were evaluated daily to monitor for complications. Duplex ultrasonography of the grafts was performed at regular intervals out to 6\u2009months to evaluate patency. At 6\u2009months, angiography and duplex was performed followed by explant for gross and histologic analysis. Technical success was achieved in 16 of 16 (100%) graft implants. No major complications, including stroke, anastomotic disruption, infection, wound breakdown, or death occurred. Primary patency of control PTFE grafts was 75% at 6\u2009months, paralleling reported rates in humans. Bilateral carotid\u2010jugular AVG implantation in sheep is a safe and durable model for self\u2010controlled long\u2010term evaluation of AVG conduit technology.<\/jats:p>","DOI":"10.1002\/ame2.70096","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T05:37:08Z","timestamp":1762321028000},"page":"1908-1914","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bilateral carotid\u2010jugular arteriovenous graft implantation in an ovine model is safe and durable for facilitation of arteriovenous graft innovation"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3434-4552","authenticated-orcid":false,"given":"Matthew","family":"Schneck","sequence":"first","affiliation":[{"name":"Department of Surgery University of California Davis  Sacramento California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Brittenham","sequence":"additional","affiliation":[{"name":"Department of Surgery University of California Davis  Sacramento California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Surgery University of California Davis  Sacramento California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taylor","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of Surgery University of California Davis  Sacramento California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Vuoncino","sequence":"additional","affiliation":[{"name":"Department of Surgery University of California Davis  Sacramento California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Pivetti","sequence":"additional","affiliation":[{"name":"Department of Surgery University of California Davis  Sacramento California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aijun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Surgery University of California Davis  Sacramento California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mimmie","family":"Kwong","sequence":"additional","affiliation":[{"name":"Department of Surgery University of California Davis  Sacramento California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,4]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"National Institutes of Health (NIH).National Institute of Diabetes and Digestive and Kidney Diseases: 2024 Annual Report. End Stage Renal Disease: Chapter\u00a01 Incidence Prevalence Patient Characteristics and Treatment Modalities.https:\/\/usrds\u2010adr.niddk.nih.gov\/2024\/end\u2010stage\u2010renal\u2010disease\/1\u2010incidence\u2010prevalence\u2010patient\u2010characteristics\u2010and\u2010treatment\u2010modalities"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2013.08.023"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.34067\/KID.0000462020"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2019.04.491"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2025.03.143"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13028-018-0397-1"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(03)00522-2"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874303X01407010033"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2009.10.080"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2017.10.038"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8191.1993.tb00574.x"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0741-5214(84)90201-5"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2020.11.028"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.TEC.2017.0217"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.34067\/KID.0003502020"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(03)00426-9"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.07.017"}],"container-title":["Animal Models and Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ame2.70096","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T06:03:24Z","timestamp":1764309804000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ame2.70096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":17,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/ame2.70096"],"URL":"https:\/\/doi.org\/10.1002\/ame2.70096","archive":["Portico"],"relation":{},"ISSN":["2576-2095","2576-2095"],"issn-type":[{"type":"print","value":"2576-2095"},{"type":"electronic","value":"2576-2095"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2025-07-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}