{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T17:53:05Z","timestamp":1787593985394,"version":"build-2736575974"},"reference-count":55,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T00:00:00Z","timestamp":1767484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T00:00:00Z","timestamp":1767484800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anim Models and Exp Med"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Healthy non\u2010pharmacological lifestyle factors, such as regular physical exercise and dietary supplementation, have been shown to significantly improve cognitive outcomes over time compared to a more sedentary lifestyle and poor diet. Furthermore, exercise may serve as a potential protective factor in attenuating the effects associated with cognitive decline that are characteristic of neurodegenerative disorders, such as Alzheimer's disease (AD). Evidence indicates that certain dietary interventions can also attenuate the effects of neurodegeneration and positively impact longevity. Supplementation with polyphenols such as ellagic acid (EA), which is abundant in pomegranate juice, may help provide neuroprotective and longevity benefits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study examined the potential protective potential of EA and exercise and provides insight into the combined use of a polyphenol\u2010rich diet and exercise to enhance behavioral outcomes and lifespan in a transgenic\n                      <jats:italic>Drosophila melanogaster<\/jats:italic>\n                      (fruit fly) model of AD with the A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      gene.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fruit flies subjected to a 120\u2010minute exercise regimen performed better on a climbing assay than flies that did not exercise. Conversely, flies that exercised for 30\u2009min passed marginally more trials on a learning and memory assay using an aversive stimulus than flies that did not exercise, whereas both groups performed better than flies subjected to the more intense exercise condition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These results suggest a hormetic effect of exercise regarding memory performance. Finally, flies fed a low dose of dietary EA (0.24\u2009mg\/mL) lived significantly longer than flies fed the control diet or higher concentrations of EA, again suggesting a hormetic effect of EA on longevity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ame2.70106","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T06:08:23Z","timestamp":1767593303000},"page":"217-236","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Polyphenol diet and exercise as neuroprotective factors in a\n                    <i>Drosophila<\/i>\n                    model of Alzheimer's disease"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8073-4925","authenticated-orcid":false,"given":"Michelle","family":"Morgan","sequence":"first","affiliation":[{"name":"School of Behavioral Health Loma Linda University  Loma Linda California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaida","family":"Lopez Rodriguez","sequence":"additional","affiliation":[{"name":"School of Behavioral Health Loma Linda University  Loma Linda California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9235-3169","authenticated-orcid":false,"given":"Richard E.","family":"Hartman","sequence":"additional","affiliation":[{"name":"School of Behavioral Health Loma Linda University  Loma Linda California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23031851"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.4324\/9781315271743"},{"issue":"2","key":"e_1_2_11_4_1","first-page":"79","article-title":"Dementia","volume":"84","author":"Cunningham EL","year":"2015","journal-title":"Ulster Med J"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13809"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-019-0244-7"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7361613"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24010778"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-02931-w"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002270"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2014.05.006"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-017-0207"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glp014"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0000000000000460"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/1407896"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3181907d69"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.2741\/e824"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-7847.70902"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2012.09.010"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-2327.40220"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.22088\/cjim.8.3.226"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2006.08.006"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161210790883615"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17122034"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23986"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.4161\/oxim.2.5.9498"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.806470"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.4155\/fso.15.63"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21093055"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-811710-1.00001-X"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crphar.2022.100120"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25042105"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5195416"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1242\/bio.049569"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.118.2.401"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-583-1_5"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.004511"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-74748-9"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005886"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00394.2019"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.21769\/BioProtoc.3037"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1249\/JES.0000000000000139"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.3791\/3786"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.3791\/2504"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0106068"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2009.00483.x"},{"key":"e_1_2_11_47_1","unstructured":"LimC KiY.Aversive phototaxic suppression (APS).2020Bio\u2010Protocol. Preprint bio\u2010protocol.org\/prep282."},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.40593"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.75389"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsos.211275"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.14440\/jbm.2016.61"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020799"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.10.065"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7432797"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.966531"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.012989"}],"container-title":["Animal Models and Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ame2.70106","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ame2.70106","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ame2.70106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T06:44:06Z","timestamp":1773384246000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ame2.70106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,4]]},"references-count":55,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/ame2.70106"],"URL":"https:\/\/doi.org\/10.1002\/ame2.70106","archive":["Portico"],"relation":{},"ISSN":["2576-2095","2576-2095"],"issn-type":[{"value":"2576-2095","type":"print"},{"value":"2576-2095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,4]]},"assertion":[{"value":"2025-06-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}