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Injectable anesthesia is suboptimal for short procedures due to variability in anesthesia duration and anesthetic side effects. Conversely, inhalational gas anesthesia offers precise titration with a rapid onset and offset. However, its use during laryngoscopy has not been documented due to existing administration techniques obstructing direct visualization of the larynx. The technique described here allows real\u2010time visualization of the rat larynx with concurrent administration of inhaled anesthetic gas. This method is particularly well\u2010suited for recurrent laryngeal nerve or vocal fold pathology studies, where repeat visualization of the larynx is necessary.<\/jats:p>","DOI":"10.1002\/ame2.70116","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T11:45:25Z","timestamp":1764762325000},"page":"2298-2301","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A novel inhaled anesthesia technique for concurrent direct laryngoscopy in rats"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5814-6590","authenticated-orcid":false,"given":"Corinne","family":"Negvesky","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery David Geffen School of Medicine University of California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6015-1247","authenticated-orcid":false,"given":"Amin","family":"Mirzaaghasi","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery David Geffen School of Medicine University of California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1262-3112","authenticated-orcid":false,"given":"Eric M.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery David Geffen School of Medicine University of California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2759-8271","authenticated-orcid":false,"given":"Ashley E.","family":"Kita","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery David Geffen School of Medicine University of California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940511400303"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpz1.995"},{"issue":"3","key":"e_1_2_11_4_1","first-page":"344","article-title":"Effect of a short\u2010term fast on ketamine\u2013xylazine anesthesia in rats","volume":"50","author":"Struck MB","year":"2011","journal-title":"J Am Assoc Lab Anim Sci"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.25122\/jml-2022-0032"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.30802\/AALAS-JAALAS-18-000032"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2008.02.017"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950x.2004.04016.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1667\/RR2304.1"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/joa.12031"},{"key":"e_1_2_11_11_1","unstructured":"Anesthetic Gases: Guidelines for Workplace Exposures | Occupational Safety and Health Administration. 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