{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T08:50:56Z","timestamp":1773391856345,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anim Models and Exp Med"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A lupus\u2010like condition induced by intraperitoneal administration of pristane (2,6,10,14\u2010tetramethylpentadecane) in mice is widely used as a model of systemic lupus erythematosus (SLE). Due to their phylogenetic distance from humans, murine models are not always suitable tool for studying the specific activity of therapeutic agents and the pathogenesis of SLE. In order to overcome species\u2010specific limitations of murine models, this approach was tested in non\u2010human primates\u2014cynomolgus monkeys (\n                    <jats:italic>Macaca fascicularis<\/jats:italic>\n                    ). Two intraperitoneal injections at a dose of 3.5\u2009mL\/kg, administered at weeks 1 and 23, recapitulated SLE features, including: production of antinuclear autoantibodies (ANA), membranoproliferative glomerulonephritis with immune complex (IC) deposition in the glomeruli. However, from week 27 five of eight pristane\u2010treated monkeys developed progressive respiratory failure. Two of these died at week\u200928 and the remaining were euthanized at week\u200932. The histology of the monkey lungs suggested exogenous lipoid pneumonia. Thus, while pristane induced serological autoimmunity and characteristic renal manifestations in\n                    <jats:italic>Macaca fascicularis<\/jats:italic>\n                    , the consequent lipoid pneumonia limited the observation period and prevented comprehensive evaluation of SLE manifestations beyond 32\u2009weeks.\n                  <\/jats:p>","DOI":"10.1002\/ame2.70130","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T09:45:56Z","timestamp":1769507156000},"page":"399-406","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Challenges of modeling pristane\u2010induced lupus in non\u2010human primates"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2566-5343","authenticated-orcid":false,"given":"Elena Vladimirovna","family":"Vinogradova","sequence":"first","affiliation":[{"name":"BIOCAD  St. Petersburg Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Alexandrovna","family":"Varavko","sequence":"additional","affiliation":[{"name":"BIOCAD  St. Petersburg Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yakov Yuryevich","family":"Ustyugov","sequence":"additional","affiliation":[{"name":"BIOCAD  St. Petersburg Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexey Alexandrovich","family":"Aleksandrov","sequence":"additional","affiliation":[{"name":"BIOCAD  St. Petersburg Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitry Alexandrovich","family":"Khochenkov","sequence":"additional","affiliation":[{"name":"FSBI \u201cNational Medical Research Center of Oncology named after. N.N. Blokhin\u201d of the Ministry of Health of the Russian Federation  Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulia Nikolaevna","family":"Linkova","sequence":"additional","affiliation":[{"name":"BIOCAD  St. Petersburg Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-023-05306-5"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076578"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/09612033221079771"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2665-9913(21)00291-5"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61354-2"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-217101"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30613"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000412"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2022.2050691"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.050125"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2019.11.006"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.46497\/ArchRheumatol.2022.8252"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem117"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2009.06.003"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.7.5101"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20080462"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jmp.12280"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40930"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.7.4777"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3638562"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.24.10934"}],"container-title":["Animal Models and Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ame2.70130","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ame2.70130","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ame2.70130","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T06:43:21Z","timestamp":1773384201000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ame2.70130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,27]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/ame2.70130"],"URL":"https:\/\/doi.org\/10.1002\/ame2.70130","archive":["Portico"],"relation":{},"ISSN":["2576-2095","2576-2095"],"issn-type":[{"value":"2576-2095","type":"print"},{"value":"2576-2095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,27]]},"assertion":[{"value":"2025-09-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}