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Transplant treatment was then followed for 6\u2009weeks in the right STR. Apomorphine (APO)\u2010induced rotation behavior and the pole climbing test were used to assess the effects of transplant treatment in each group. Western blotting (WB) and immunofluorescence staining were used to observe changes in endogenous NSCs. The effect of ethyl stearate on qNSCs was examined in\u00a0vitro, with detection of associated indicators achieved through WB, immunofluorescence, flow cytometry and qRT\u2010PCR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Co\u2010transplantation of NSCs with ethyl stearate significantly ameliorated motor deficits in PD rats and upregulated the expression of tyrosine hydroxylase (TH), Sox2, and Nestin. We established an in\u00a0vitro system for NSC quiescence and activation. In qNSCs, ethyl stearate treatment increased Ki67 positivity and reduced the proportion of cells in the G0\u2013G1 phase of the cell cycle, whereas withdrawal of ethyl stearate exerted the opposite effects. Ethyl stearate also downregulated EphB2 protein levels and upregulated p\u2010AKT and CyclinD1 in qNSCs; these effects were reversed upon its removal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings imply that co\u2010transplantation of NSCs and ethyl stearate may help ameliorate motor impairment in PD rats by activating endogenous NSCs and promoting their development into dopaminergic neurons. Ethyl stearate may regulate the entry and exit of NSCs from quiescence through the EphB2\/AKT\/CyclinD1 pathway.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ame2.70138","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T09:21:02Z","timestamp":1772961662000},"page":"249-263","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neural stem cells\u00a0transplantation combined with ethyl stearate promotes the activation of quiescent NSCs\u00a0and improves\n                    <scp>PD<\/scp>\n                    rats motor behavior"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7055-0454","authenticated-orcid":false,"given":"Xiaoxiao","family":"Yang","sequence":"first","affiliation":[{"name":"School of Basic Medical Sciences Guangzhou University of Chinese Medicine  Guangzhou China"},{"name":"Research Center of Basic Integrative Medicine, 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