{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:59:13Z","timestamp":1785437953708,"version":"3.56.0"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T00:00:00Z","timestamp":1773532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T00:00:00Z","timestamp":1773532800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anim Models and Exp Med"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The development of nonhuman primate models that replicate human systemic lupus erythematosus (SLE) remains limited. This study aimed to develop a pristane\u2010induced SLE model in\n                      <jats:italic>Macaca fascicularis<\/jats:italic>\n                      and evaluate its capacity to mimic human\u2010like clinical and laboratory immunological alterations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      An experimental, single\u2010arm investigation was performed using six female\n                      <jats:italic>M. fascicularis<\/jats:italic>\n                      (2\u20133\u2009years old, 3\u20134\u2009kg), which received a single intraperitoneal pristane injection (5\u2009mL\/kg body weight) to induce SLE and were monitored biweekly.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Throughout the 24\u2010week study period, all macaques developed hallmark SLE\u2010like changes without requiring a booster, including a pronounced increase in antinuclear antibody titers (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002), with anti\u2010dsDNA positivity detected at the study endpoint. Significant decline was observed in hemoglobin, leukocyte, and lymphocyte count (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), reflecting hematologic perturbations consistent with human SLE. Physiologic deterioration, manifested as hyperthermia and weight loss, also emerged early (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). Biochemical assessment demonstrated mild hepatic and renal dysfunction marked by elevated serum glutamic pyruvic transaminase (SGPT) and urea concentrations (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Uniform proteinuria further indicated renal involvement, although the absence of hematuria suggests a spectrum of renal injury that may be less severe than that observed in advanced human SLE and may require longer observation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Overall, the reproducibility of autoantibody elevation and multisystem involvement demonstrates the model's translational potential. This nonhuman primate model offers a significant framework for investigating SLE pathogenesis and assessing novel therapy approaches.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ame2.70162","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T05:45:26Z","timestamp":1773639926000},"page":"1302-1309","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phenotypic profiling of pristane\u2010induced mimicking human systemic lupus erythematosus in\n                    <i>Macaca fascicularis<\/i>"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8564-7430","authenticated-orcid":false,"given":"Jonny","family":"Jonny","sequence":"first","affiliation":[{"name":"Doctoral Program of Medical Science, Faculty of Medicine Universitas Airlangga  Surabaya Indonesia"},{"name":"Indonesia Army Cell Cure Center Gatot Soebroto Central Army Hospital  Jakarta 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