{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T22:20:33Z","timestamp":1783117233924,"version":"3.54.6"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T00:00:00Z","timestamp":1773532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T00:00:00Z","timestamp":1773532800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003718","name":"Korea Institute of Oriental Medicine","doi-asserted-by":"publisher","award":["KSN2225011"],"award-info":[{"award-number":["KSN2225011"]}],"id":[{"id":"10.13039\/501100003718","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008783","name":"National Research Council of Science and Technology","doi-asserted-by":"publisher","award":["GTL25071\u2010000"],"award-info":[{"award-number":["GTL25071\u2010000"]}],"id":[{"id":"10.13039\/501100008783","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anim Models and Exp Med"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Scalp electroacupuncture (SA) has been clinically used as a novel treatment for ischemic stroke and depression. This study aimed to investigate whether stimulation of SA of the Baihui (GV20) and Yintang (EX\u2010HN3) acupoints, which regulate the trigeminal nerve (TN), can alleviate depression and anxiety caused by post\u2010traumatic stress disorder (PTSD) and to identify its therapeutic mechanism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>After stimulation of SA, vasodilation and leakage within the TN area and c\u2010Fos expression in the TN pathway of the brain were analyzed. Also, the anti\u2010inflammatory, antidepressant, and anxiolytic effects of SA were investigated in a mouse model of PTSD induced by single prolonged stress.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>SA activated the TN pathway, inducing vasodilation along the TN pathway, and increased c\u2010Fos expression in the brain, including the spinal trigeminal nucleus, locus coeruleus (LC), amygdala, and entorhinal cortex. SA significantly alleviated depression\u2010 and anxiety\u2010related behaviors, decreased pro\u2010inflammatory cytokines, and increased the expression of neurotrophic factors in the hippocampus. Also, SA decreased the expression of P2X7 receptors in the microglia and norepinephrine transporter in the LC and hippocampus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results demonstrated that SA exhibited anti\u2010inflammatory, antidepressant, and anxiolytic effects through the P2X7 receptor pathway and the LC\u2010norepinephrine system.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ame2.70164","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T06:36:46Z","timestamp":1773643006000},"page":"991-1001","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Scalp electroacupuncture targeting trigeminal nerve activation alleviates post\u2010traumatic stress disorder\u2013induced depression and neuroinflammation in mice"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8447-9941","authenticated-orcid":false,"given":"Bombi","family":"Lee","sequence":"first","affiliation":[{"name":"Acupuncture and Meridian Science Research Center, College of Korean Medicine Kyung Hee University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoongeun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Graduate School Kyung Hee University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyungjun","family":"Kim","sequence":"additional","affiliation":[{"name":"KM Science Research Division Korea Institute of Oriental Medicine  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae\u2010Hyun","family":"Hahm","sequence":"additional","affiliation":[{"name":"Acupuncture and Meridian Science Research Center, College of Korean Medicine Kyung Hee University  Seoul Republic of Korea"},{"name":"Department of Biomedical Sciences, Graduate School Kyung Hee University  Seoul Republic of Korea"},{"name":"Department of Physiology, College of Medicine Kyung Hee University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,15]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874467214666210525160944"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2015.17.2\/jflory"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2017.91"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9020107"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2021.641570"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20112778"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2023.02.015"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-3999(02)00429-4"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2015.09.007"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2016.04.014"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-021-01244-4"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14447"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1210537"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2023.137056"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S405728"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/158987"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nec.2011.07.001"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2017.01.060"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1089\/acu.2017.1231"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.31.436"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11418-022-01636-z"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-30337-5"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1083066"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2024.1468331"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jams.2016.11.006"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2017.08.012"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2020.03.004"},{"key":"e_1_2_13_29_1","first-page":"13","article-title":"The trigeminal (V) and facial (VII) cranial nerves: head and face sensation and movement","volume":"7","author":"Sanders RD","year":"2010","journal-title":"Psychiatry (Edgmont)"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2023.1130989"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.112330"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-07219-3"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1532-2149.2012.00174.x"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00030"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-017-0865-y"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12459"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2008.47"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2021.725091"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-021-05908-6"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2005.12.001"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2015.11.014"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-45106-5_9"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2023.102477"}],"container-title":["Animal Models and Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ame2.70164","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ame2.70164","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ame2.70164","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:34:53Z","timestamp":1783114493000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ame2.70164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,15]]},"references-count":42,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/ame2.70164"],"URL":"https:\/\/doi.org\/10.1002\/ame2.70164","archive":["Portico"],"relation":{},"ISSN":["2576-2095","2576-2095"],"issn-type":[{"value":"2576-2095","type":"print"},{"value":"2576-2095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,15]]},"assertion":[{"value":"2025-08-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}