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However, systematic investigations of the proteome and phosphoproteome across multiple organs of this species\u2009remain limited.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive proteomic and phosphoproteomic analysis was performed across\u2009nine major organs of the Chinese hamster, including\u2009heart, liver, lung, kidney, spleen, cerebral cortex, skeletal muscle, stomach, and testis or ovary.\u2009High\u2010throughput mass spectrometry\u2013based approaches were used to identify and quantify proteins and phosphorylation sites across these tissues.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 14\u2009219 proteins were identified in the proteome, with 11\u2009828 phosphorylated proteins and 47\u2009122 phosphorylation sites in the phosphoproteome. The comparative analysis revealed pronounced interorgan differences in protein composition and phosphorylation regulation, reflecting distinct physiological functions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This work provides a systematic framework for understanding organ\u2010specific functions of the Chinese hamster and establishes a theoretical basis for its use as a disease model, filling a critical gap in multiorgan proteomic and posttranslational modification datasets for this species.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ame2.70176","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T04:39:18Z","timestamp":1773808758000},"page":"785-795","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A comprehensive proteome and phosphoproteome atlas across nine organs of the Chinese hamster"],"prefix":"10.1002","volume":"9","author":[{"given":"Luyao","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Common Mechanism Research for Major Diseases, Department of Biochemistry and Molecular Biology Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Ding","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Common Mechanism Research for Major Diseases, Department of Biochemistry and Molecular Biology Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanjun","family":"Peng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Common Mechanism Research for Major Diseases, Department 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