{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T22:19:00Z","timestamp":1783117140559,"version":"3.54.6"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800785"],"award-info":[{"award-number":["81800785"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972085"],"award-info":[{"award-number":["81972085"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172465"],"award-info":[{"award-number":["82172465"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["SZXK025"],"award-info":[{"award-number":["SZXK025"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024YZZ13"],"award-info":[{"award-number":["2024YZZ13"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anim Models and Exp Med"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study aimed to investigate the potential causal relationship between genetically predicted human blood cell (HBC) reactivity and disorders of bone continuity, density, and structure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed summary\u2010level GWAS data for 91 HBC traits and two bone\u2010related outcomes from publicly available sources, employing the inverse\u2010variance weighted (IVW) method as the principal Mendelian randomization (MR) technique. The sensitivity analyses comprised MR\u2010Egger regression and MR\u2010PRESSO.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      MR analysis identified suggestive associations between red blood cell (RBC) perturbation response (Pam3CSK4), neutrophil perturbation response (side fluorescence coefficient of variation of neutrophil 4), Neutrophil perturbation response (colchicine), Monocyte perturbation response (TMAO perturbation) and bone continuity. The MR results are: [\n                      <jats:italic>\u03b2<\/jats:italic>\n                      : \u22120.13, odds ratio (OR): 0.88; 95% confidence interval (CI): 0.77, 0.99;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.040], [\n                      <jats:italic>\u03b2<\/jats:italic>\n                      : 0.11, OR: 1.12, 95% CI: 1.02, 1.23;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016], [\n                      <jats:italic>\u03b2<\/jats:italic>\n                      : \u22120.11, OR: 0.90, 95% CI: 0.81, 0.99;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.029] and [\n                      <jats:italic>\u03b2<\/jats:italic>\n                      : \u22120.04, OR: 0.96, 95% CI: 0.92, 0.99;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.023]. In addition, Neutrophil perturbation response (forward scatter median of neutrophil 1), Unknown cell population perturbation response (nigericin) and other disorders of bone density and structure are also potential causal factors, with MR Result [\n                      <jats:italic>\u03b2<\/jats:italic>\n                      : 0.21, OR: 1.24, 95%CI: 1.01, 1.51;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.034], [\n                      <jats:italic>\u03b2<\/jats:italic>\n                      : 0.03, OR: 1.03, 95% CI: 1.00, 1.06;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.042]. Reverse Mendelian randomization sensitivity analysis showed a potential bidirectional association between specific HBC features and bone\u2010related outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This exploratory study offer valuable preliminary insights into the blood cell functional reactivity and bone health. The findings, while requiring independent validation, highlight plausible biological pathways for further elucidation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ame2.70187","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T13:17:06Z","timestamp":1775222226000},"page":"932-946","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genetic prediction of blood cell reactivity and its potential causal influence on bone continuity and density disorders"],"prefix":"10.1002","volume":"9","author":[{"given":"Zhiqin","family":"Deng","sequence":"first","affiliation":[{"name":"Hand and Foot Surgery Department Shenzhen Second People's Hospital\/The First Hospital Affiliated to Shenzhen University, Medical Innovation Technology Transformation Center of Shenzhen Second People's Hospital  Shenzhen 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