{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:15:11Z","timestamp":1784556911804,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T00:00:00Z","timestamp":1778371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T00:00:00Z","timestamp":1778371200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100014219","name":"National Science Fund for Distinguished Young Scholars","doi-asserted-by":"publisher","award":["81925025"],"award-info":[{"award-number":["81925025"]}],"id":[{"id":"10.13039\/501100014219","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anim Models and Exp Med"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Hepatitis A virus (HAV) is an important pathogen that has continuously posed a threat to global public health for over 5000\u2009years. The development of accessible and reliable small animal models, especially murine models, is essential for elucidating HAV pathogenesis and advancing preventive and therapeutic strategies. The first mouse model for HAV infection was established using human\u2010liver chimeric mice, which supported robust viral replication and high viral loads. Later, an\n                    <jats:italic>Ifnar1<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>\u2212\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    mice model was established with a specific mouse\u2010adapted strain, recapitulating key clinical features of human hepatitis A. Recently, to overcome limitations associated with the difficulty in obtaining and amplifying stocks of HAV for animal models, our laboratory established a novel hepatitis A mouse model using lipid nanoparticle\u2010encapsulated viral genomic RNA (LNP\u2010vRNA). This approach provides a new strategy for modeling infections of hard\u2010to\u2010culture RNA viruses. In this review, we systematically summarize and compare these mouse models, respectively highlighting their advantages and limitations, and offer guidance for their application in future HAV research.\n                  <\/jats:p>","DOI":"10.1002\/ame2.70219","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T04:25:13Z","timestamp":1778473513000},"page":"1180-1187","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Advances and perspectives in animal models of human hepatitis A virus"],"prefix":"10.1002","volume":"9","author":[{"given":"Jian","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Pathogen and Biosecurity Academy of Military Medical Sciences  Beijing China"},{"name":"School of Basic Medicine Sciences Tsinghua University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei\u2010Yu","family":"Jiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogen and Biosecurity Academy of Military Medical Sciences  Beijing China"},{"name":"School of Basic Medicine Sciences Tsinghua University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogen and Biosecurity Academy of Military Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0632-2807","authenticated-orcid":false,"given":"Cheng\u2010Feng","family":"Qin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogen and Biosecurity Academy of Military Medical Sciences  Beijing China"},{"name":"Research Unit of Discovery and Tracing of Natural Focus Diseases Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,10]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.08.034"},{"key":"e_1_2_12_3_1","first-page":"493","article-title":"WHO position paper on hepatitis A vaccines","volume":"97","author":"WHO","year":"2022","journal-title":"Wkly Epidemiol Rec"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40249-019-0591-z"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2020.1769389"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6818a2"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a033480"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a031674"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a031815"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.09.013"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.20.1.28-33.1984"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.32.1.388-393.1981"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/138.3.369"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/134.1.80"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1086\/340520"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/132.5.532"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf8325"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2025.101582"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2024-332784"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00969-17"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.04.023"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009960"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.07.019"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20892"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2008.07.006"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.28189"},{"key":"e_1_2_12_27_1","unstructured":"PangD.To HAV or Not to HAV: Novel Hepatitis A Virus (HAV) Infection in a Chimeric Mouse Model.2013. 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