{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:57:10Z","timestamp":1792180630173,"version":"4.4.0"},"reference-count":184,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anim Models and Exp Med"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by amyloid\u2010\u03b2 (A\u03b2) deposition. The liver\u2010brain axis underscores the central role of the liver in modulating cognitive function through multidimensional regulatory mechanisms. As a core metabolic and detoxification organ, the liver also helps maintain cerebral homeostasis via pathways including the urea cycle, antioxidant systems, ketone body metabolism, and bile acid regulation. Dysfunction of these processes may lead to ammonia accumulation, exacerbated oxidative stress, and A\u03b2 clearance, thereby accelerating the pathological progression of AD. Liver\u2010derived factors such as apolipoprotein E (APOE), C\u2010reactive protein (CRP), fibroblast growth factor 21 (FGF21), and insulin\u2010like growth factor 1 (IGF\u20101) significantly increase the risk of AD through dual mechanisms\u2010inhibiting A\u03b2 clearance and activating neuroinflammation, thereby directly affecting cognitive function via modulation of inflammation, metabolism, and blood\u2013brain barrier (BBB) integrity. Neural interfaces formed by the hypothalamic\u2013pituitary\u2010target gland axis and the vagus nerve enable communication from the liver to the brain, with emerging evidence also supporting a reverse influence from the brain to the liver. Emerging technologies such as molecular tracing and nanocarriers provide new tools for deciphering dynamic interactions within the liver\u2010brain axis. Liver\u2010targeted metabolic interventions show potential for reversing cognitive impairment. Unlike previous reviews that mainly focused on single pathways, this review conceptualizes the liver\u2010brain axis as a multidimensional regulatory network in AD. By clearly linking network nodes to potential therapeutic interventions, it provides us with a novel framework that not only describes the various mechanisms but also focuses on identifying actionable targets for disease prevention and treatment.<\/jats:p>","DOI":"10.1002\/ame2.70262","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T13:31:52Z","timestamp":1784640712000},"page":"1743-1760","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The liver\u2010brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications"],"prefix":"10.1002","volume":"9","author":[{"given":"Ning","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Ultrasound, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Experimental and Translational Research Center, Beijing Friendship Hospital Capital Medical University  Beijing China"},{"name":"State Key Lab of Digestive Health, Beijing Friendship Hospital Capital Medical University  Beijing China"},{"name":"National Clinical Research Center of Digestive Diseases, Beijing Friendship Hospital Capital Medical University  Beijing China"},{"name":"Beijing Clinical Research Institute, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32055"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2468-1253(24)00320-0"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(20)32205-4"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.08.021"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2023.06.002"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2015.05.002"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.13622"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-0072-x"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-023-02559-z"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M706316200"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006312"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2021.08.010"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-05842-9"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021-326269"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2001.7732"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-47897-y"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21653"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-52815-3"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc4346"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.05.042"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-01746-z"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2020.104931"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2018.03.029"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0197-4580(03)00087-3"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.08.004"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12502"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2011.03.005"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ado1855"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-017-1297-5"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2024.105079"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2015.119"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2013.08.007"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-018-0286-0"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.11.013"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.01.032"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14173"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0000000000207358"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2017.04.014"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2022.102014"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-019-01269-1"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.Atv.0000206211.21895.73"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2009.308"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000073620.42047.d7"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/agm2.12044"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.05.030"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-019-0536-8"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.30773\/pi.2020.0205"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2023.1227325"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.67969"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-024-01472-y"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9092807"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2019.07.015"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43856-022-00234-0"},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101333"},{"key":"e_1_2_14_56_1","doi-asserted-by":"publisher","DOI":"10.1159\/000343302"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lab.2005.07.010"},{"key":"e_1_2_14_58_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871527319666200812223007"},{"key":"e_1_2_14_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2025.119390"},{"key":"e_1_2_14_60_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242216288"},{"key":"e_1_2_14_61_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29174056"},{"key":"e_1_2_14_62_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41232-023-00277-3"},{"key":"e_1_2_14_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2025.04.014"},{"key":"e_1_2_14_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2025.05.011"},{"key":"e_1_2_14_65_1","doi-asserted-by":"publisher","DOI":"10.20945\/2359-4292-2022-0493"},{"key":"e_1_2_14_66_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-025-00849-6"},{"key":"e_1_2_14_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-022-01679-4"},{"key":"e_1_2_14_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101483"},{"key":"e_1_2_14_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-026-01091-5"},{"key":"e_1_2_14_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13679-016-0216-9"},{"key":"e_1_2_14_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2025.102955"},{"key":"e_1_2_14_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2023.114371"},{"key":"e_1_2_14_73_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076518"},{"key":"e_1_2_14_74_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14204298"},{"key":"e_1_2_14_75_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.44370"},{"key":"e_1_2_14_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-022-02741-6"},{"key":"e_1_2_14_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2022.11.003"},{"key":"e_1_2_14_78_1","doi-asserted-by":"publisher","DOI":"10.2337\/db11-0672"},{"key":"e_1_2_14_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110439"},{"key":"e_1_2_14_80_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-01921-2"},{"key":"e_1_2_14_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-024-01462-x"},{"key":"e_1_2_14_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2022.104896"},{"key":"e_1_2_14_83_1","doi-asserted-by":"publisher","DOI":"10.1530\/jme-17-0311"},{"key":"e_1_2_14_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2013.67"},{"key":"e_1_2_14_85_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18071447"},{"key":"e_1_2_14_86_1","doi-asserted-by":"publisher","DOI":"10.2741\/403"},{"key":"e_1_2_14_87_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-024-04457-1"},{"key":"e_1_2_14_88_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5300.661"},{"key":"e_1_2_14_89_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci59903"},{"key":"e_1_2_14_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(89)90355-7"},{"key":"e_1_2_14_91_1","doi-asserted-by":"publisher","DOI":"10.3233\/jad-190921"},{"key":"e_1_2_14_92_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-019-01827-y"},{"key":"e_1_2_14_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2021.105191"},{"key":"e_1_2_14_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1202-793"},{"key":"e_1_2_14_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2005.06.015"},{"key":"e_1_2_14_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1703"},{"key":"e_1_2_14_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2023.137189"},{"key":"e_1_2_14_98_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12959"},{"key":"e_1_2_14_99_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21249675"},{"key":"e_1_2_14_100_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.00200"},{"key":"e_1_2_14_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-020-00435-y"},{"key":"e_1_2_14_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2022.101619"},{"key":"e_1_2_14_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0306-4522(96)00395-8"},{"key":"e_1_2_14_104_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.24163"},{"key":"e_1_2_14_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2011.128"},{"key":"e_1_2_14_106_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M004531200"},{"key":"e_1_2_14_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2004.07.040"},{"key":"e_1_2_14_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2022.09.032"},{"key":"e_1_2_14_109_1","doi-asserted-by":"publisher","DOI":"10.1159\/000479508"},{"key":"e_1_2_14_110_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23179540"},{"key":"e_1_2_14_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2017.02.030"},{"key":"e_1_2_14_112_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0905686106"},{"key":"e_1_2_14_113_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology10090938"},{"key":"e_1_2_14_114_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2220684120"},{"key":"e_1_2_14_115_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-021-00784-w"},{"key":"e_1_2_14_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2022.03.001"},{"key":"e_1_2_14_117_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222212310"},{"key":"e_1_2_14_118_1","doi-asserted-by":"publisher","DOI":"10.3109\/10715762.2014.987274"},{"key":"e_1_2_14_119_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12999"},{"key":"e_1_2_14_120_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-022-1807-7"},{"key":"e_1_2_14_121_1","doi-asserted-by":"publisher","DOI":"10.3233\/jad-221147"},{"key":"e_1_2_14_122_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2024.1369493"},{"key":"e_1_2_14_123_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23074022"},{"key":"e_1_2_14_124_1","doi-asserted-by":"publisher","DOI":"10.1039\/d0fo02364g"},{"key":"e_1_2_14_125_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40200-025-01597-6"},{"key":"e_1_2_14_126_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.736580"},{"key":"e_1_2_14_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.105314"},{"key":"e_1_2_14_128_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2024.2374608"},{"key":"e_1_2_14_129_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-023-02289-5"},{"key":"e_1_2_14_130_1","doi-asserted-by":"publisher","DOI":"10.3233\/jad-230570"},{"key":"e_1_2_14_131_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-025-02094-x"},{"key":"e_1_2_14_132_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abm6131"},{"key":"e_1_2_14_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2024.109888"},{"key":"e_1_2_14_134_1","doi-asserted-by":"publisher","DOI":"10.3233\/jad-221175"},{"key":"e_1_2_14_135_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41393-022-00788-9"},{"key":"e_1_2_14_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2025.04.029"},{"key":"e_1_2_14_137_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05797.x"},{"key":"e_1_2_14_138_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23073533"},{"key":"e_1_2_14_139_1","doi-asserted-by":"publisher","DOI":"10.3233\/adr-210299"},{"key":"e_1_2_14_140_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21218338"},{"key":"e_1_2_14_141_1","doi-asserted-by":"publisher","DOI":"10.1002\/edm2.386"},{"key":"e_1_2_14_142_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-025-05275-2"},{"key":"e_1_2_14_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2021.10.014"},{"key":"e_1_2_14_144_1","doi-asserted-by":"publisher","DOI":"10.1042\/bst20220434"},{"key":"e_1_2_14_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2023.101223"},{"key":"e_1_2_14_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2025.103578"},{"key":"e_1_2_14_147_1","doi-asserted-by":"publisher","DOI":"10.1039\/d1fo01471d"},{"key":"e_1_2_14_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2022.148197"},{"key":"e_1_2_14_149_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-023-2353-0"},{"key":"e_1_2_14_150_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.4c07035"},{"key":"e_1_2_14_151_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40268-021-00345-4"},{"key":"e_1_2_14_152_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.70033"},{"key":"e_1_2_14_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2022.05.011"},{"key":"e_1_2_14_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2024.01.024"},{"key":"e_1_2_14_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.08.013"},{"key":"e_1_2_14_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2023.110647"},{"key":"e_1_2_14_157_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-240899"},{"issue":"1","key":"e_1_2_14_158_1","first-page":"7","article-title":"Leptin, leptin receptors and the control of body weight","volume":"2","author":"Friedman JM","year":"1997","journal-title":"Eur J Med Res"},{"key":"e_1_2_14_159_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051341"},{"key":"e_1_2_14_160_1","doi-asserted-by":"publisher","DOI":"10.1590\/s0100-879x2011007500113"},{"key":"e_1_2_14_161_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1548"},{"key":"e_1_2_14_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.08.035"},{"key":"e_1_2_14_163_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.026609"},{"key":"e_1_2_14_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.10.015"},{"key":"e_1_2_14_165_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-020-1767-5"},{"key":"e_1_2_14_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2024.07.019"},{"key":"e_1_2_14_167_1","doi-asserted-by":"publisher","DOI":"10.1038\/35013070"},{"key":"e_1_2_14_168_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02440"},{"key":"e_1_2_14_169_1","doi-asserted-by":"publisher","DOI":"10.4183\/aeb.2019.25"},{"key":"e_1_2_14_170_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/3100943"},{"key":"e_1_2_14_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2021.01.003"},{"key":"e_1_2_14_172_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-10-55"},{"key":"e_1_2_14_173_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2011.02217.x"},{"key":"e_1_2_14_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2024.10.011"},{"key":"e_1_2_14_175_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-025-10288-7"},{"key":"e_1_2_14_176_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejm199505183322008"},{"key":"e_1_2_14_177_1","first-page":"2000","volume-title":"Endotext","author":"Mariotti S","year":"2000"},{"key":"e_1_2_14_178_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2021.111173"},{"key":"e_1_2_14_179_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-018-0110-9"},{"key":"e_1_2_14_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2017.12.007"},{"key":"e_1_2_14_181_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.04.042"},{"key":"e_1_2_14_182_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2007.01.038"},{"key":"e_1_2_14_183_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.546350"},{"key":"e_1_2_14_184_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2009.03.007"},{"key":"e_1_2_14_185_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-024-01659-x"}],"container-title":["Animal Models and Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ame2.70262","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ame2.70262","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ame2.70262","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T15:24:54Z","timestamp":1791732294000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ame2.70262"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,21]]},"references-count":184,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/ame2.70262"],"URL":"https:\/\/doi.org\/10.1002\/ame2.70262","archive":["Portico"],"relation":{},"ISSN":["2576-2095","2576-2095"],"issn-type":[{"value":"2576-2095","type":"print"},{"value":"2576-2095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,21]]},"assertion":[{"value":"2026-03-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}