{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T16:36:53Z","timestamp":1793205413806,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005089","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7262112"],"award-info":[{"award-number":["7262112"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anim Models and Exp Med"],"published-print":{"date-parts":[[2026,10]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Hypoxic pulmonary hypertension (HPH) is a progressive chronic disorder characterized by elevated mean pulmonary arterial pressure. It severely impairs right ventricular function and ultimately causes right ventricular failure. Clarifying the complex pathogenesis of HPH remains a critical challenge.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Rat HPH models were established by exposure to a hypobaric hypoxia chamber for 4 consecutive weeks. Lung tissues were harvested for RNA sequencing. The Coding\u2010Non\u2010Coding Index (CNCI) and Coding Potential Calculator (CPC) were used to construct a competing endogenous RNA (ceRNA) network. Pulmonary artery endothelial cells were transfected with modified\n lncRNA\u201092467<\/jats:italic>\n or\n miR\u2010205\u20105p<\/jats:italic>\n to assess their regulatory functions. Finally, mice were injected with AAV\u2010Control or AAV\u2010\n PTPRM<\/jats:italic>\n shRNA (2.5\u2009\u00d7\u200910\n 11<\/jats:sup>\n v.g.\/mL per mouse). Hemodynamic and echocardiographic analyses were performed to evaluate the in\u00a0vivo role of\n PTPRM<\/jats:italic>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n We identified that\n lncRNA\u201092467<\/jats:italic>\n functions as a competing endogenous RNA (ceRNA) by competitively binding to\n miR\u2010205\u20105p<\/jats:italic>\n , thereby upregulating its target gene\n PTPRM<\/jats:italic>\n . Knockdown of\n lncRNA\u201092467<\/jats:italic>\n significantly promoted pulmonary artery endothelial cell proliferation and migration. These effects were abolished by a\n miR\u2010205\u20105p<\/jats:italic>\n inhibitor, which also restored\n PTPRM<\/jats:italic>\n expression. Functional assays confirmed that\n miR\u2010205\u20105p<\/jats:italic>\n enhanced cell proliferation and migration while inhibiting apoptosis; these effects were reversed by\n PTPRM<\/jats:italic>\n overexpression. In\u00a0vivo, exogenous\n PTPRM<\/jats:italic>\n overexpression attenuated HPH progression in mice. Mechanistically,\n PTPRM<\/jats:italic>\n directly targeted cell adhesion molecules (CAMs), which increased catenin production, thereby inhibiting abnormal cell proliferation and migration and promoting apoptosis.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Our findings reveal a novel\n lncRNA\u201092467<\/jats:italic>\n \/\n miR\u2010205\u20105p<\/jats:italic>\n \/\n PTPRM<\/jats:italic>\n \/\n CAMs<\/jats:italic>\n regulatory axis in HPH pathogenesis. These results suggest that\n PTPRM<\/jats:italic>\n may serve as a promising therapeutic target for HPH.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ame2.70267","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T04:18:58Z","timestamp":1786421938000},"page":"1913-1927","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genome\u2010wide network analysis identifies the\n lncRNA\u201092467\/miR\u2010205\u20105p\/PTPRM\/CAMs<\/i>\n axis in a rat model of hypoxic pulmonary hypertension"],"prefix":"10.1002","volume":"9","author":[{"given":"Yan\u2010Ying","family":"Shen","sequence":"first","affiliation":[{"name":"Medical Innovation Research Department of PLA General Hospital Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Bing","family":"Chen","sequence":"additional","affiliation":[{"name":"Medical Innovation Research Department of PLA General Hospital Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"Medical Innovation Research Department of PLA General Hospital Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Xu","sequence":"additional","affiliation":[{"name":"Medical Innovation Research Department of PLA General Hospital Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Guo","sequence":"additional","affiliation":[{"name":"Medical Innovation Research Department of PLA General Hospital Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han\u2010Lu","family":"Li","sequence":"additional","affiliation":[{"name":"Medical Innovation Research Department of PLA General Hospital Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010Ming","family":"Yao","sequence":"additional","affiliation":[{"name":"Medical Innovation Research Department of PLA General Hospital Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Lei","family":"Liu","sequence":"additional","affiliation":[{"name":"Medical Innovation Research Department of PLA General Hospital Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-019-1240-7"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13020-022-00689-2"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/10641963.2021.1984501"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2NH00348A"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2018-105387"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2025.2522973"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2024.107439"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.70577"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.121310"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1962"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt646"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm391"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbw053"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.26850"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.7312"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.14202"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-023-02401-y"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.124.321416"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2019.06.023"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.116769"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrtlng.2022.04.002"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2025.2486990"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.2174\/156800961407140926105634"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1722"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.09-149724"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.22099\/mbrc.2024.50390.1996"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2039"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2021.1944220"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-02826-x"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-022-07846-8"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11182904"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2023.117487"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-024-03068-7"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2012.150"}],"container-title":["Animal Models and Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ame2.70267","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ame2.70267","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ame2.70267","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T15:57:54Z","timestamp":1793203074000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ame2.70267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,10]]},"references-count":34,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/ame2.70267"],"URL":"https:\/\/doi.org\/10.1002\/ame2.70267","archive":["Portico"],"relation":{},"ISSN":["2576-2095","2576-2095"],"issn-type":[{"value":"2576-2095","type":"print"},{"value":"2576-2095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,10]]},"assertion":[{"value":"2026-03-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}