{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T16:19:18Z","timestamp":1787674758699,"version":"build-2784847793"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Anim Models and Exp Med"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Aging impairs quality of life, making experimental models essential to evaluate interventions that modulate age\u2010related changes. This study aimed to characterize a modified D\u2010galactose\u2010induced aging model and explore the effects of intermittent low\u2010dose ozone exposure on redox balance and functional outcomes. Twenty\u2010seven 12\u2010week\u2010old male Wistar rats were randomly assigned to healthy, aging (D\u2010galactose induction), and ozone\u2010treated (D\u2010galactose + ozone) groups. Plasma and skin MDA levels, SOD activity, and GSH levels were measured colorimetrically. Physical performance was assessed using physical health score, morbidity proportion, body weight, muscle strength (hanging test), hair regrowth, and skin structure (Hematoxylin\u2013Eosin and Masson's trichrome staining). Compared with healthy rats, the aging group showed increased plasma MDA levels (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.007), MDA\/SOD ratios (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.005), and MDA\/GSH ratios (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.016). In ozone\u2010treated rats, plasma MDA and MDA\/SOD tended to decrease compared with aging rats, while GSH tended to increase. In the skin, redox markers were comparable across groups, except for a significantly lower MDA\/SOD ratio in the ozone\u2010treated group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.043) compared with the aging group. D\u2010Galactose induction reduced physical health (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.017), increased morbidity, and tended to reduce body\u2010weight gain and hanging ability. Ozone\u2010treated rats showed improved physical health (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.041), lower morbidity, accelerated hair regrowth, and preserved skin structure, particularly dermal firmness and collagen thickness (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.013). The modified D\u2010galactose model partially induced redox imbalance and functional deterioration, whereas intermittent low\u2010dose ozone exposure tended to restore redox homeostasis, preserve physical health, accelerate hair regrowth, and maintain the skin structure without inducing supraphysiological effects.\n                  <\/jats:p>","DOI":"10.1002\/ame2.70271","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T04:37:50Z","timestamp":1785386270000},"page":"1690-1698","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A modified D\u2010galactose\u2010induced aging rat model with low\u2010dose intraperitoneal ozone: Redox, functional, and skin outcomes"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0138-2659","authenticated-orcid":false,"given":"Isabella Kurnia","family":"Liem","sequence":"first","affiliation":[{"name":"Department of Anatomy, Faculty of Medicine Universitas Indonesia  Jakarta Indonesia"},{"name":"School of Medicine and Health Sciences Atma Jaya Catholic University of Indonesia  Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raisa","family":"Nauli","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Faculty of Medicine Universitas Indonesia  Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firda Asma\u2019ul","family":"Husna","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Faculty of Medicine Universitas Indonesia  Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasanthy","family":"Kusumaningtyas","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Faculty of Medicine Universitas Indonesia  Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deswaty","family":"Furqonita","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Faculty of Medicine Universitas Indonesia  Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferbian Milas","family":"Siswanto","sequence":"additional","affiliation":[{"name":"School of Medicine and Health Sciences Atma Jaya Catholic University of Indonesia  Jakarta Indonesia"},{"name":"Department of Biochemistry, School of Medicine and Health Sciences Atma Jaya Catholic University of Indonesia  Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soegianto","family":"Ali","sequence":"additional","affiliation":[{"name":"School of Medicine and Health Sciences Atma Jaya Catholic University of Indonesia  Jakarta Indonesia"},{"name":"Department of Biology, School of Medicine and Health Sciences Atma Jaya Catholic University of Indonesia  Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01251-0"},{"key":"e_1_2_12_3_1","unstructured":"World Health Organization: WHO.Ageing and health.2024.https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/ageing\u2010and\u2010health"},{"key":"e_1_2_12_4_1","volume-title":"Angka Harapan Hidup (AHH) Menurut Provinsi dan Jenis Kelamin\u2014Tabel Statistik","author":"Indonesia BPS","year":"2023"},{"key":"e_1_2_12_5_1","volume-title":"Survei Kesehatan Indonesia (SKI) 2023","author":"Badan Kebijakan Pembangunan Kesehatan 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