{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T17:46:59Z","timestamp":1783360019006,"version":"3.54.6"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T00:00:00Z","timestamp":1488758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acute Medicine &amp; Surgery"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>For patients with inhalation injury, the indications for early intubation are diverse. The purpose of this study was to identify the most reliable symptoms, physical findings, and medical examinations with which to determine the indications for early intubation in patients with inhalation injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively collected patient data from medical records. Collected data included age, sex, burn size, symptoms, physical findings, carboxyhemoglobin levels (<jats:styled-content style=\"fixed-case\">COH<\/jats:styled-content>b), and bronchial wall thickness (<jats:styled-content style=\"fixed-case\">BWT<\/jats:styled-content>) determined from chest computed tomography images. We analyzed the relationships between these findings and the early intubation. We performed fiberoptic bronchoscopy in all patients, and analyzed the relationships between bronchoscopic severity and other findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 205 patients, 80 patients were diagnosed as having inhalation injury, and 34 patients were intubated. Burn size, facial burns, neck burns, use of accessory respiratory muscles, and <jats:styled-content style=\"fixed-case\">COH<\/jats:styled-content>b seemed to be related with intubation, whereas singed nasal hair was not. If the patients suffered \u226527% total body surface area burn and <jats:styled-content style=\"fixed-case\">BWT<\/jats:styled-content> \u22653.5 mm, the positive predictive value for early intubation was 1.00. If the patients suffered smaller cutaneous burn without neck burn, and their <jats:styled-content style=\"fixed-case\">COH<\/jats:styled-content>b &lt;4.0%, the negative predictive value for early intubation was 0.97. Fiberoptic bronchoscopy findings from above the glottis were mainly related with patients\u2019 symptoms. Findings from below the glottis were mainly related with <jats:styled-content style=\"fixed-case\">BWT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">COH<\/jats:styled-content>b.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients\u2019 symptoms, especially use of accessory respiratory muscles, are reliable, and <jats:styled-content style=\"fixed-case\">BWT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">COH<\/jats:styled-content>b are also useful tools, for determining the indication for early intubation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ams2.269","type":"journal-article","created":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T08:33:27Z","timestamp":1488789207000},"page":"278-285","source":"Crossref","is-referenced-by-count":25,"title":["Indications of early intubation for patients with inhalation injury"],"prefix":"10.1002","volume":"4","author":[{"given":"Shinya","family":"Onishi","sequence":"first","affiliation":[{"name":"Department of Trauma, Critical Care Medicine and Burn Center Japan Community Health Care Organization Chukyo Hospital Nagoya AICHI Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7575-7927","authenticated-orcid":false,"given":"Akinori","family":"Osuka","sequence":"additional","affiliation":[{"name":"Department of Trauma, Critical Care Medicine and Burn Center Japan Community Health Care Organization Chukyo Hospital Nagoya AICHI Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Kuroki","sequence":"additional","affiliation":[{"name":"Department of Trauma, Critical Care Medicine and Burn Center Japan Community Health Care Organization Chukyo Hospital Nagoya AICHI Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Ueyama","sequence":"additional","affiliation":[{"name":"Department of Trauma, Critical Care Medicine and Burn Center Japan Community Health Care Organization Chukyo Hospital Nagoya AICHI Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2006.07.007"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2004.10.016"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-4179(98)00092-8"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198701000-00015"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(88)80357-3"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-199012001-00015"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TA.0000083609.24440.7F"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2006.11.009"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1996.81.5.2250"},{"issue":"6","key":"e_1_2_7_11_1","first-page":"948","article-title":"Proteasomes in human bronchoalveolar lavage fluid after burn and inhalation injury","volume":"30","author":"Albright JM","year":"2009","journal-title":"J. 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