{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:48:41Z","timestamp":1768438121213,"version":"3.49.0"},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,7,13]],"date-time":"2017-07-13T00:00:00Z","timestamp":1499904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acute Medicine &amp; Surgery"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:title>Case<\/jats:title><jats:p>Disseminated cryptococcosis is a well\u2010recognized condition among <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> patients, but it also occurs in non\u2010<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> patients. Necrotizing fasciitis caused by cryptococcus is rare. An 81\u2010year\u2010old man who had received steroid therapy presented with erythema and pain in his right thigh. After the rapid progression of symptoms and a failure to respond to antibiotic therapy, a clinical diagnosis of necrotizing fasciitis was made. We performed debridement, and yeasts were detected using a Gram stain of the fascia. We treated the patient with liposomal amphotericin B. On day 3, he developed meningitis. <jats:italic>Cryptococcus neoformans<\/jats:italic> was detected in the blood, fascia, and cerebrospinal fluid. Flucytosine was added to liposomal amphotericin B.<\/jats:p><\/jats:sec><jats:sec><jats:title>Outcome<\/jats:title><jats:p>Despite the antifungal treatment, new regions of dissemination to the skin developed, and the patient died of multiple organ failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A diagnosis of disseminated cryptococcosis should be considered in a differential diagnosis of necrotizing fasciitis among immunocompromised patients, regardless of their <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> status.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ams2.298","type":"journal-article","created":{"date-parts":[[2017,7,13]],"date-time":"2017-07-13T12:45:28Z","timestamp":1499949928000},"page":"454-457","source":"Crossref","is-referenced-by-count":4,"title":["A case of disseminated cryptococcosis with necrotizing fasciitis in a non\u2010<scp>HIV<\/scp> patient"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5981-6117","authenticated-orcid":false,"given":"Tetsuya","family":"Hoshino","sequence":"first","affiliation":[{"name":"Department of Intensive Care Medicine Saiseikai Yokohamashi Tobu Hospital Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuya","family":"Omura","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Saiseikai Yokohamashi Tobu Hospital Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Saiseikai Yokohamashi Tobu Hospital Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Saiseikai Yokohamashi Tobu Hospital Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhiko","family":"Kamei","sequence":"additional","affiliation":[{"name":"Division of Clinical Research Medical Mycology Research Center Chiba University Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Misako","family":"Ohkusu","sequence":"additional","affiliation":[{"name":"Division of Clinical Research Medical Mycology Research Center Chiba University Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3855\/jidc.2479"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/13693780701675797"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2007.01357.x"},{"key":"e_1_2_6_5_1","unstructured":"Disseminated cryptococcal infection in Japan (2014 Week 39\u20102015 Week 37) [homepage on the internet].Tokyo:National Institute of infectious diseases[updated Oct 2015; cited 19 Dec 2016]. 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