{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T17:25:52Z","timestamp":1776792352888,"version":"3.51.2"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T00:00:00Z","timestamp":1538611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acute Medicine &amp; Surgery"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To examine lymphocyte counts as a predictive prognostic marker in patients with coma after cardiac arrest.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively evaluated patients with coma after cardiac arrest admitted to the intensive care unit of Shiga University of Medical Science (Otsu, Japan). Lymphocyte counts were measured for 6\u00a0days from admission. Neurological outcome was assessed as favorable or unfavorable using cerebral performance categories. Associations between lymphocyte count and prognosis were investigated using multivariate logistic regression analysis and receiver operating characteristic curves.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010six patients were assessed from February 2012 to December 2016. Survivors had significantly higher lymphocyte counts than non\u2010survivors on days 2 and 5. Multivariate analysis showed that lymphocyte count was not associated with 90\u2010day mortality. Patients with favorable neurological outcome at discharge had significantly higher lymphocyte counts on days 2\u20136 than patients with unfavorable outcomes. Multivariate logistic regression analysis, including possible confounders, showed that lymphocyte counts on days 2\u20134 and 6 were associated with neurological outcome (day 2: odds ratio [OR]\u00a0=\u00a00.75, 95% confidence interval [CI]\u00a0=\u00a00.58\u20130.97, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.029; day 3: OR\u00a0=\u00a00.68, 95% CI\u00a0=\u00a00.47\u20130.98, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.04; day 4: OR\u00a0=\u00a00.4, 95% CI\u00a0=\u00a00.16\u20131.00, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.05; day 6: OR\u00a0=\u00a00.69, 95% CI\u00a0=\u00a00.48\u20130.99, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.046). Receiver operating characteristic curve analysis indicated high accuracy for predicting neurological outcome for each lymphocyte count on days 2\u20136 using the area under the curve, day 4 values being most accurate (day 2: 0.776, day 3: 0.787, day 4: 0.909, day 5: 0.774, day 6: 0.839).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Lymphocyte counts on days 2\u20134 and 6 after cardiac arrest are associated with neurological outcome; counts on day 4 most accurately predict neurological outcome.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ams2.374","type":"journal-article","created":{"date-parts":[[2018,10,6]],"date-time":"2018-10-06T02:55:28Z","timestamp":1538794528000},"page":"30-39","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Association between lymphocyte count and neurological outcomes in post\u2010cardiac arrest patients treated with mild therapeutic hypothermia"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7358-0769","authenticated-orcid":false,"given":"Hidemitsu","family":"Miyatake","sequence":"first","affiliation":[{"name":"Department of Critical and Intensive Care Medicine Shiga University of Medical Science Otsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunori","family":"Fujino","sequence":"additional","affiliation":[{"name":"Department of Critical and Intensive Care Medicine Shiga University of Medical Science Otsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachiko","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics Shiga University of Medical Science Otsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyuki","family":"Tsujita","sequence":"additional","affiliation":[{"name":"Department of Critical and Intensive Care Medicine Shiga University of Medical Science Otsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Horie","sequence":"additional","affiliation":[{"name":"Center for Epidemiologic Research in Asia Shiga University of Medical Science Otsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Eguchi","sequence":"additional","affiliation":[{"name":"Department of Critical and Intensive Care Medicine Shiga University of Medical Science Otsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2010.08.006"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1161\/CIRCULATIONAHA.108.190652","article-title":"Post\u2010cardiac arrest syndrome: epidemiology, pathophysiology, treatment, and prognostication. A consensus statement from the International Liaison Committee on Resuscitation; the American Heart Association Emergency Cardiovascular Care Committee; the Council on Cardiovascular Surgery and Anesthesia; the Council on Cardiopulmonary, Perioperative, and Critical Care; the Council on Clinical Cardiology; and the Stroke Council","volume":"118","author":"Nolan JP","year":"2008","journal-title":"Circulation"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-017-1766-2"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2017.05.006"},{"key":"e_1_2_8_6_1","first-page":"215","article-title":"Changes in neutrophil\u2010to\u2010lymphocyte ratios in postcardiac arrest patients treated with targeted temperature management","volume":"18","author":"Baser K","year":"2017","journal-title":"Anatol. J. 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