{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T12:34:27Z","timestamp":1784810067529,"version":"3.55.0"},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T00:00:00Z","timestamp":1567382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acute Medicine &amp; Surgery"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Reye's syndrome (<jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content>) is a rare but severe acute life\u2010threating disease characterized by encephalopathy and fatty liver damage. Reye's syndrome is most common in children and rarely occurs in adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>A 56\u2010year\u2010old woman was admitted to the emergency department with disturbance of consciousness and respiratory failure. She had taken ibuprofen for headache. Her Glasgow Coma Scale score was E3V3M5 on admission. The laboratory findings revealed acute liver failure with prothrombin time \u2013 international normalized ratio of 3.16, aspartate aminotransferase 12,548\u00a0<jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>\/L, alanine aminotransferase 5,725\u00a0<jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>\/L, and blood ammonia 102\u00a0\u03bcg\/dL. Head magnetic resonance imaging showed hyperintense signals on diffusion\u2010weighed images of globus pallidus.<\/jats:p><jats:p>We diagnosed the patient with <jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content> induced by influenza A and use of ibuprofen. The patient received supportive care in the intensive care unit and her clinical outcome was favorable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ibuprofen might be a risk factor for <jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ams2.457","type":"journal-article","created":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T07:03:31Z","timestamp":1567407811000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A rare case of Reye's syndrome induced by influenza A virus with use of ibuprofen in an adult"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1655-2294","authenticated-orcid":false,"given":"Takashi","family":"Hongo","sequence":"first","affiliation":[{"name":"Emergency Department Okayama Saiseikai General Hospital Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriya","family":"Momoki","sequence":"additional","affiliation":[{"name":"Emergency Department Okayama Saiseikai General Hospital Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souichiro","family":"Mae","sequence":"additional","affiliation":[{"name":"Emergency Department Okayama Saiseikai General Hospital Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Nozaki","sequence":"additional","affiliation":[{"name":"Emergency Department Okayama Saiseikai General Hospital Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Emergency Department Okayama Saiseikai General Hospital Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshifumi","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Emergency Department Okayama Saiseikai General Hospital Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199905063401801"},{"key":"e_1_2_6_3_1","first-page":"528","article-title":"Refractory epilepsy status in Reye's syndrome in an adult. A case report","volume":"35","author":"Tihista J","year":"2002","journal-title":"Rev. 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