{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:16:51Z","timestamp":1777655811641,"version":"3.51.4"},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T00:00:00Z","timestamp":1579132800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acute Medicine &amp; Surgery"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Euglycemic diabetic ketoacidosis is a critical clinical presentation that can occur during treatment with sodium\u2010glucose cotransporter 2 inhibitors. However, little is known regarding how a low\u2010carbohydrate diet in combination with this treatment can increase the risk for this condition. Here, we report a case of euglycemic diabetic ketoacidosis in a patient treated with sodium\u2010glucose cotransporter 2 inhibitors after initiation of a low\u2010carbohydrate diet.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Presentation<\/jats:title><jats:p>A 54\u2010year\u2010old woman who was taking canagliflozin was transferred to our hospital with severe dyspnea. She had been started on a strict low\u2010carbohydrate diet for 6\u00a0days before admission. Laboratory evaluation revealed severe ketoacidosis and a blood glucose level of 196\u00a0mg\/dL. After her symptoms improved, she was diagnosed with type 1 diabetes mellitus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although low\u2010carbohydrate diets are recommended for patients with diabetes mellitus, physicians should exercise great caution in recommending low\u2010carbohydrate diets to patients undergoing treatment with sodium\u2010glucose cotransporter 2 inhibitors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ams2.480","type":"journal-article","created":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T23:41:02Z","timestamp":1579218062000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Euglycemic diabetic ketoacidosis due to a strict low\u2010carbohydrate diet during treatment with sodium\u2010glucose cotransporter 2 inhibitors"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3809-1572","authenticated-orcid":false,"given":"Yuita","family":"Fukuyama","sequence":"first","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Tokyo Bay Urayasu Ichikawa Medical Center Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Numata","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Tokyo Bay Urayasu Ichikawa Medical Center Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaede","family":"Yoshino","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine Tokyo Bay Urayasu Ichikawa Medical Center Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takushi","family":"Santanda","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Tokyo Bay Urayasu Ichikawa Medical Center Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5828-6986","authenticated-orcid":false,"given":"Hiraku","family":"Funakoshi","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Tokyo Bay Urayasu Ichikawa Medical Center Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc15-1380"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc15-1995"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12214"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2886"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-9032"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60591-7"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.112.042457"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60613-9"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2016.03.020"}],"container-title":["Acute Medicine &amp; Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ams2.480","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ams2.480","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ams2.480","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T13:06:44Z","timestamp":1693746404000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ams2.480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1002\/ams2.480"],"URL":"https:\/\/doi.org\/10.1002\/ams2.480","archive":["Portico"],"relation":{},"ISSN":["2052-8817","2052-8817"],"issn-type":[{"value":"2052-8817","type":"print"},{"value":"2052-8817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"2019-04-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e480"}}