{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:34:03Z","timestamp":1788395643322,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T00:00:00Z","timestamp":1581465600000},"content-version":"vor","delay-in-days":42,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science London","doi-asserted-by":"publisher","award":["[A] 16H02634"],"award-info":[{"award-number":["[A] 16H02634"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science London","doi-asserted-by":"publisher","award":["[A] 19H01075"],"award-info":[{"award-number":["[A] 19H01075"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["H30\u2010seisaku\u2010shitei\u2010004"],"award-info":[{"award-number":["H30\u2010seisaku\u2010shitei\u2010004"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acute Medicine &amp; Surgery"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To describe the epidemiology of patients on extracorporeal membrane oxygenation (ECMO) and investigate the possible association between outcomes for respiratory ECMO patients and hospital volume of ECMO treatment for any indications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using data from the Diagnosis Procedure Combination database, a nationwide Japanese inpatient database, between 1 July 2010 and 31 March 2018, we identified inpatients aged \u226518\u00a0years who underwent ECMO. Institutional case volume was defined as the mean annual number of ECMO cases; eligible patients were categorized into institutional case volume tertile groups. The primary outcome was in\u2010hospital mortality. For ECMO patients with respiratory failure, the association between institutional case volume group and in\u2010hospital mortality rate was analyzed using a multilevel logistic regression model including multiple imputation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Extracorporeal membrane oxygenation was carried out on 25,384 patients during the study period; of those, 1,227 cases were for respiratory failure. Respiratory cases were categorized into low\u2010 (&lt;8 cases\/year), medium\u2010 (8\u201316 cases\/year), and high\u2010volume groups (\u226517 cases\/year). The overall in\u2010hospital mortality rate for respiratory ECMO was 62.5% in low\u2010, 54.7% in medium\u2010, and 50.4% in high\u2010volume institutions. With reference to low\u2010volume institutions, the adjusted odds ratios (95% confidence interval) of the medium\u2010 and high\u2010volume institutions for in\u2010hospital mortality were 0.72 (0.50\u20131.04;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.082) and 0.65 (0.45\u20130.95;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.024), respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The present study showed that accumulating the experience of using ECMO for any indications could positively affect the outcome of ECMO treatment for respiratory failure, which suggests the effectiveness of consolidating ECMO cases in high\u2010volume centers in Japan.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ams2.486","type":"journal-article","created":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T04:19:55Z","timestamp":1581481195000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Epidemiology and volume\u2010outcome relationship of extracorporeal membrane oxygenation for respiratory failure in Japan: A retrospective observational study using a national administrative database"],"prefix":"10.1002","volume":"7","author":[{"given":"Kohei","family":"Muguruma","sequence":"first","affiliation":[{"name":"Department of Healthcare Economics and Quality Management Graduate School of Medicine Kyoto University Kyoto City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susumu","family":"Kunisawa","sequence":"additional","affiliation":[{"name":"Department of Healthcare Economics and Quality Management Graduate School of Medicine Kyoto University Kyoto City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyohide","family":"Fushimi","sequence":"additional","affiliation":[{"name":"Department of Health Policy and Informatics Graduate School of Medicine Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4613-2159","authenticated-orcid":false,"given":"Yuichi","family":"Imanaka","sequence":"additional","affiliation":[{"name":"Department of Healthcare Economics and Quality Management Graduate School of Medicine Kyoto University Kyoto City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,12]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Extracorporeal Life Support Organization.General Guidelines for all ECLS cases. [cited 2 Octover 2019.]https:\/\/www.elso.org\/Portals\/0\/ELSO%20Guidelines%20General%20All%20ECLS%20Version%201_4.pdf."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000475"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2018.08.012"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1535"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1471"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-010-2021-3"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201409-1634OC"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201404-0630CP"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-012-1402-x"},{"key":"e_1_2_8_11_1","unstructured":"Japanese society ofPercutaneousCardio\u2010Pulmonary Support\/Extracorporeal Membrane Oxygenation.Questionnaire result. (in Japanese.) [cited 2 Octover 2019.]http:\/\/www2.convention.co.jp\/pcps\/dl\/enquete.pdf."},{"key":"e_1_2_8_12_1","unstructured":"NonprofitOrganization Japanese Society of Education for Physicians and Trainees in Intensive Care.Questionnaire result. (in Japanese.) [cited 2 Octover 2019.]http:\/\/www.jseptic.com\/rinsho\/questionnaire.html."},{"key":"e_1_2_8_13_1","unstructured":"Ministry of Health Labour and Welfare.Overviews of revised medical fee in 2018. (in Japanese.) [cited 2 Octover 2019.]https:\/\/www.mhlw.go.jp\/file\/06-Seisakujouhou-12400000-Hokenkyoku\/0000197983.pdf."},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2016.02.009"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2018.07.012"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201311-2023OC"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780100410"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2393"},{"key":"e_1_2_8_19_1","unstructured":"Japanese Society of Respiratory Care Medicine.Overviews of simulation\u2010based training of ECMO. (in Japanese.) [cited 2 Octover 2019.]http:\/\/square.umin.ac.jp\/jrcm\/contents\/ecmo\/index.html."},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40560-018-0306-8"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa053993"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1357"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2014.06.025"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2015.02.037"},{"key":"e_1_2_8_25_1","first-page":"314","article-title":"Simulation training aimed at the establishment of a mobile ECMO system. (in Japanese.) Journal of Japanese Association for","volume":"28","author":"Hagiwara Y","year":"2017","journal-title":"Acute Med."}],"updated-by":[{"DOI":"10.1002\/ams2.511","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T00:00:00Z","timestamp":1587427200000}}],"container-title":["Acute Medicine &amp; Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ams2.486","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ams2.486","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ams2.486","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T09:03:25Z","timestamp":1693731805000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ams2.486"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1002\/ams2.486"],"URL":"https:\/\/doi.org\/10.1002\/ams2.486","archive":["Portico"],"relation":{},"ISSN":["2052-8817","2052-8817"],"issn-type":[{"value":"2052-8817","type":"print"},{"value":"2052-8817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"2019-11-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e486"}}