{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T20:11:40Z","timestamp":1780344700320,"version":"3.54.1"},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T00:00:00Z","timestamp":1587340800000},"content-version":"vor","delay-in-days":110,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acute Medicine &amp; Surgery"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Acute mitral regurgitation could occur without common symptoms like hemodynamic instability, but with dyspnea, hemoptysis, and right\u2010sided infiltration on radiography. We report a case of severe alveolar hemorrhage caused by acute mitral regurgitation, which occurred in the absence of shock.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Presentation<\/jats:title><jats:p>A 40\u2010year\u2010old man presented with dyspnea with bloody phlegm and hypoxia, despite being hemodynamically stable. Chest radiography revealed right\u2010sided infiltration, and bronchoscopy showed fresh bloody phlegm in his tracheae. No specific findings were detected with any tests. After treatment with several medications and support with extracorporeal membrane oxygenation, his condition improved, although the etiology of the disease remained unknown. Transthoracic and transesophageal echocardiogram revealed severe mitral valve regurgitation with ruptured mitral chordae tendineae. These suggested that the sudden onset of mitral valve regurgitation had caused severe alveolar hemorrhage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Severe alveolar hemorrhage, especially with right\u2010sided infiltration on chest radiography, should be considered a symptom of acute mitral regurgitation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ams2.504","type":"journal-article","created":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T05:53:46Z","timestamp":1587448426000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Acute mitral valve regurgitation causing severe alveolar hemorrhage"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6922-1280","authenticated-orcid":false,"given":"Ayaka","family":"Sakamoto","sequence":"first","affiliation":[{"name":"Department of Emergency and Critical Care Medicine University of Tsukuba Hospital Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3052-8602","authenticated-orcid":false,"given":"Yuki","family":"Enomoto","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine University of Tsukuba Hospital Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Watabe","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine University of Tsukuba Hospital Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuaki","family":"Koyama","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine University of Tsukuba Hospital Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukei","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine University of Tsukuba Hospital Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobutake","family":"Shimojo","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine University of Tsukuba Hospital Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiki","family":"Marushima","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine University of Tsukuba Hospital Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Kawano","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine University of Tsukuba Hospital Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine University of Tsukuba Hospital Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.782292"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-200093010-00013"},{"key":"e_1_2_6_4_1","first-page":"3","article-title":"Diffuse alveolar hemorrhage and intravascular hemolysis due to acute mitral valve regurgitation","volume":"16","author":"Yeung AW","year":"2013","journal-title":"Crit. 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Pulmonol."},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199506083322308"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.54.3057"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001340051183"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2014.12.016"}],"container-title":["Acute Medicine &amp; Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ams2.504","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ams2.504","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ams2.504","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T13:05:07Z","timestamp":1693746307000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ams2.504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1002\/ams2.504"],"URL":"https:\/\/doi.org\/10.1002\/ams2.504","archive":["Portico"],"relation":{},"ISSN":["2052-8817","2052-8817"],"issn-type":[{"value":"2052-8817","type":"print"},{"value":"2052-8817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"2020-01-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e504"}}