{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:34:40Z","timestamp":1790836480436,"version":"4.1.0"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T00:00:00Z","timestamp":1620000000000},"content-version":"vor","delay-in-days":122,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acute Medicine &amp; Surgery"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Auto\u2010brewery syndrome (ABS) is often caused by fungi in the intestinal tract. We describe a rare case of alcohol production by <jats:italic>Candida albicans<\/jats:italic> and periodontal disease bacteria in the oral cavity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Presentation<\/jats:title><jats:p>A man aged in his 60s had a car accident, and alcohol was detected on his breath. At the time, he exhibited alcohol overdose seizures with no alcohol consumption. We carried out a gastrointestinal endoscopy, detected esophageal candidiasis, and diagnosed ABS. His seizures continued despite using miconazole oral gel. Significant tooth decay, periodontal disease, and high <jats:italic>C.\u00a0albicans<\/jats:italic> levels were observed in his oral cavity. Alcohol production was confirmed from periodontal bacteria and <jats:italic>C.\u00a0albicans<\/jats:italic> cultures and alcohol\u2010degrading enzyme functions were poor. Dental treatment and antifungal drugs reduced seizures, and improved his fatty liver.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Alcohol can be produced by microorganisms in healthy individuals. Therefore, blood alcohol levels and alcohol\u2010degrading enzyme functions should be examined in patients with unexplained liver dysfunction.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ams2.652","type":"journal-article","created":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T10:52:50Z","timestamp":1620039170000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Auto\u2010brewery syndrome caused by oral fungi and periodontal disease bacteria"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5947-6295","authenticated-orcid":false,"given":"Gaku","family":"Takahashi","sequence":"first","affiliation":[{"name":"Department of Critical Care, Disaster and General Medicine School of Medicine Iwate Medical University Morioka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Hoshikawa","sequence":"additional","affiliation":[{"name":"Department of Critical Care, Disaster and General Medicine School of Medicine Iwate Medical University Morioka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigenori","family":"Kan","sequence":"additional","affiliation":[{"name":"Department of Critical Care, Disaster and General Medicine School of Medicine Iwate Medical University Morioka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rise","family":"Akimaru","sequence":"additional","affiliation":[{"name":"Department of Critical Care, Disaster and General Medicine School of Medicine Iwate Medical University Morioka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Kodama","sequence":"additional","affiliation":[{"name":"Department of Critical Care, Disaster and General Medicine School of Medicine Iwate Medical University Morioka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiro","family":"Sato","sequence":"additional","affiliation":[{"name":"Division of Preventive Dentistry Department of Oral Medicine School of Dentistry Iwate Medical University Morioka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Kakisaka","sequence":"additional","affiliation":[{"name":"Division of Hepatology Department of Internal Medicine School of Medicine Iwate Medical University Morioka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Central Clinical Laboratory Iwate Medical University Hospital Morioka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,3]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"429","article-title":"The auto\u2010brewery syndrome\u2013the repeated attacks of alcoholic intoxication due to the overgrowth of Candida (albicans) in the gastrointestinal tract","volume":"8","author":"Kaji H","year":"1976","journal-title":"Mater. Med. Pol."},{"key":"e_1_2_6_3_1","first-page":"e5904","article-title":"A case of auto\u2010brewery syndrome treated with micafungin","volume":"11","author":"Saverimuttu J","year":"2019","journal-title":"Cureus"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/2164956119837566"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"e000325","DOI":"10.1136\/bmjgast-2019-000325","article-title":"Case report and literature review of auto\u2010brewery syndrome: probably an underdiagnosed medical condition","volume":"6","author":"Fahad M","year":"2019","journal-title":"BMJ Open Gastroenterol."},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.7326\/L19-0661"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2041-1626.2011.00078.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1355-0306(04)71707-4"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2001.tb02244.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyg026"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.08.018"}],"container-title":["Acute Medicine &amp; Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ams2.652","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ams2.652","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ams2.652","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T11:44:16Z","timestamp":1692618256000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ams2.652"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1002\/ams2.652"],"URL":"https:\/\/doi.org\/10.1002\/ams2.652","archive":["Portico"],"relation":{},"ISSN":["2052-8817","2052-8817"],"issn-type":[{"value":"2052-8817","type":"print"},{"value":"2052-8817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"2020-12-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e652"}}