{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:01:32Z","timestamp":1787241692534,"version":"build-2736575974"},"reference-count":1061,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T00:00:00Z","timestamp":1629936000000},"content-version":"vor","delay-in-days":237,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acute Medicine &amp; Surgery"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J\u2010SSCG 2020), a Japanese\u2010specific set of clinical practice guidelines for sepsis and septic shock created as revised from J\u2010SSCG 2016 jointly by the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine, was first released in September 2020 and published in February 2021. An English\u2010language version of these guidelines was created based on the contents of the original Japanese\u2010language version. The purpose of this guideline is to assist medical staff in making appropriate decisions to improve the prognosis of patients undergoing treatment for sepsis and septic shock. We aimed to provide high\u2010quality guidelines that are easy to use and understand for specialists, general clinicians, and multidisciplinary medical professionals. J\u2010SSCG 2016 took up new subjects that were not present in SSCG 2016 (e.g., ICU\u2010acquired weakness [ICU\u2010AW], post\u2010intensive care syndrome [PICS], and body temperature management). The J\u2010SSCG 2020 covered a total of 22 areas with four additional new areas (patient\u2010 and family\u2010centered care, sepsis treatment system, neuro\u2010intensive treatment, and stress ulcers). A total of 118 important clinical issues (clinical questions, CQs) were extracted regardless of the presence or absence of evidence. These CQs also include those that have been given particular focus within Japan. This is a large\u2010scale guideline covering multiple fields; thus, in addition to the 25 committee members, we had the participation and support of a total of 226 members who are professionals (physicians, nurses, physiotherapists, clinical engineers, and pharmacists) and medical workers with a history of sepsis or critical illness. The GRADE method was adopted for making recommendations, and the modified Delphi method was used to determine recommendations by voting from all committee members.<\/jats:p>\n                  <jats:p>As a result, 79 GRADE\u2010based recommendations, 5 Good Practice Statements (GPS), 18 expert consensuses, 27 answers to background questions (BQs), and summaries of definitions and diagnosis of sepsis were created as responses to 118 CQs. We also incorporated visual information for each CQ according to the time course of treatment, and we will also distribute this as an app. The J\u2010SSCG 2020 is expected to be widely used as a useful bedside guideline in the field of sepsis treatment both in Japan and overseas involving multiple disciplines.<\/jats:p>","DOI":"10.1002\/ams2.659","type":"journal-article","created":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T02:39:29Z","timestamp":1630031969000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J\u2010SSCG 2020)"],"prefix":"10.1002","volume":"8","author":[{"given":"Moritoki","family":"Egi","sequence":"first","affiliation":[{"name":"Division of Anesthesiology Department of Surgery Related Kobe University Graduate School of Medicine Kobe 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