{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T10:26:12Z","timestamp":1768559172232,"version":"3.49.0"},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,8,8]],"date-time":"2014-08-08T00:00:00Z","timestamp":1407456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of Health, Labour and Welfare of Japan","award":["2013-2015"],"award-info":[{"award-number":["2013-2015"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acute Medicine &amp; Surgery"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec><jats:title>Case<\/jats:title><jats:p>A healthy 40\u2010year\u2010old man was admitted with severe coagulopathy that developed after <jats:styled-content style=\"fixed-case\"><jats:italic>R<\/jats:italic><\/jats:styled-content><jats:italic>habdophis tigrinus<\/jats:italic> bites. On admission, he showed significantly elevated levels of thrombin\u2013antithrombin III complex (60\u2009ng\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>), plasmin\u2013alpha 2\u2010plasmin inhibitor complex (22.3\u2009\u03bcg\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>), and fibrinogen degradation products (592\u2009\u03bcg\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>). He subsequently developed severe hypofibrinogenemia (50\u2009mg\/<jats:styled-content style=\"fixed-case\">dL<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Outcome<\/jats:title><jats:p>Antivenom was given 28\u2009h after the patient was bitten, following which his hemorrhagic symptoms resolved. By day 3 of admission, scabs had formed over the bite wounds. Furthermore, his fibrinogen levels increased to &gt;100\u2009mg\/<jats:styled-content style=\"fixed-case\">dL<\/jats:styled-content>, while his thrombin\u2013antithrombin III complex, plasmin\u2013alpha 2\u2010plasmin inhibitor complex, and fibrinogen degradation product levels normalized. He was discharged on day 6 of admission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>Rhabdophis\u2009tigrinus<\/jats:italic> bites induced disseminated intravascular coagulation with a fibrinolytic phenotype, which completely recovered with antivenom treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ams2.69","type":"journal-article","created":{"date-parts":[[2014,8,8]],"date-time":"2014-08-08T11:10:48Z","timestamp":1407496248000},"page":"123-126","source":"Crossref","is-referenced-by-count":12,"title":["Potentially fatal coagulopathy secondary to yamakagashi (<scp><i>R<\/i><\/scp><i>habdophis tigrinus<\/i>) bites that completely recovered with antivenom treatment"],"prefix":"10.1002","volume":"2","author":[{"given":"Toru","family":"Hifumi","sequence":"first","affiliation":[{"name":"Emergency Medical Center Kagawa University Hospital  Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Murakawa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kaizuka Hospital  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Sakai","sequence":"additional","affiliation":[{"name":"The Japan Snake Institute  Ota Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiko","family":"Ginnaga","sequence":"additional","affiliation":[{"name":"The Chemo\u2010Sero\u2010Therapeutic Research Institute  Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiko","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Bacteriology II National Institute of Infectious Disease  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manabu","family":"Ato","sequence":"additional","affiliation":[{"name":"Department of Immunology National Institute of Infectious Disease  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kato","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine and Trauma National Hospital Organization Disaster Medical Center  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Koido","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine and Trauma National Hospital Organization Disaster Medical Center  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenya","family":"Kawakita","sequence":"additional","affiliation":[{"name":"Emergency Medical Center Kagawa University Hospital  Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanobu","family":"Hagiike","sequence":"additional","affiliation":[{"name":"Emergency Medical Center Kagawa University Hospital  Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Kuroda","sequence":"additional","affiliation":[{"name":"Emergency Medical Center Kagawa University Hospital  Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"397","DOI":"10.7883\/yoken.64.397","article-title":"Experimental manufacture of equine antivenom against yamakagashi (Rhabdophis tigrinus)","volume":"64","author":"Morokuma K","year":"2011","journal-title":"Jpn J. 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