{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T18:50:06Z","timestamp":1764874206052,"version":"3.41.2"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T00:00:00Z","timestamp":1735171200000},"content-version":"vor","delay-in-days":360,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acute Medicine &amp; Surgery"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Vertebral artery dissection (VAD) is a rare cause of non\u2010traumatic subarachnoid hemorrhage (SAH) with significant clinical implications. This study compared the clinical characteristics and outcomes of SAH from intracranial VAD rupture to those from other etiologies, primarily aneurysmal rupture.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This single\u2010center retrospective cohort study at Okayama University Hospital included patients with non\u2010traumatic SAH diagnosed between 2019 and 2023. Patients were categorized into \u201cVAD rupture\u201d and \u201cother etiologies\u201d groups. The main outcome was clinical presentation and symptoms. Additional outcomes included ICU mortality, in\u2010hospital mortality, and unfavorable outcomes at discharge and 6\u2009months, defined as a modified Rankin Scale score of 3\u20136.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 66 patients were included, with 14 in the VAD rupture group and 52 in the other etiologies group. The VAD rupture group was younger (median age 49 vs. 64\u2009years, <jats:italic>p<\/jats:italic>\u2009=\u20090.003) and had a higher incidence of out\u2010of\u2010hospital cardiac arrest (42.9% vs. 9.6%, <jats:italic>p<\/jats:italic>\u2009=\u20090.011). Preceding headache was more common in the VAD rupture group (78.6% vs. 11.5%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), with a median duration of 36\u2009h before presentation. ICU and in\u2010hospital mortality was higher in the VAD rupture group (both 50.0% vs. 19.3%, <jats:italic>p<\/jats:italic>\u2009=\u20090.019). No significant differences were found in unfavorable neurological outcomes at hospital discharge and 6\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>VAD\u2010related SAH often presents with prodromal headaches, severe symptoms like out\u2010of\u2010hospital cardiac arrest, and higher ICU and in\u2010hospital mortality than other SAH causes, though long\u2010term outcomes are similar. Larger, prospective studies are needed to refine interventions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ams2.70031","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T01:08:27Z","timestamp":1735261707000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Characteristics and outcomes of subarachnoid hemorrhage from vertebral artery dissection: A comparative study with other non\u2010traumatic etiologies"],"prefix":"10.1002","volume":"11","author":[{"given":"Shu","family":"Oshita","sequence":"first","affiliation":[{"name":"Okayama University Medical School  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Yumoto","sequence":"additional","affiliation":[{"name":"Department of Emergency, Critical Care, and Disaster Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama University  Okayama 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Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Sugiu","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama University  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shota","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama University  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6818-2985","authenticated-orcid":false,"given":"Atsunori","family":"Nakao","sequence":"additional","affiliation":[{"name":"Department of Emergency, Critical Care, and Disaster Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama University  Okayama 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