{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T06:55:41Z","timestamp":1791701741836,"version":"4.3.4"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:00:00Z","timestamp":1735862400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acute Medicine &amp; Surgery"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Hypothermia\u2010associated pancreatitis lacks comprehensive understanding owing to limited studies exploring its mechanism, epidemiology, risk factors, and outcomes. We aimed to investigate the frequency, characteristics, and predictive factors associated with the development of acute pancreatitis in patients with accidental hypothermia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study comprised a post hoc analysis of data from a multicenter prospective observational study (ICE\u2010CRASH study) conducted in 36 tertiary emergency hospitals in Japan. Patients aged \u226518\u2009years with core body temperatures \u226432\u00b0C admitted to emergency departments between 2019 and 2022 were enrolled. We identified patients who developed acute pancreatitis within 1\u2009week of admission and described their characteristics. Age, vital signs, and blood gas analysis data were analyzed as potential predictors of acute pancreatitis using receiver operating characteristic (ROC) curve analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 421 eligible patients with accidental hypothermia, 16 (3.8%) developed acute pancreatitis within 1\u2009week. The age distribution of patients with acute pancreatitis showed bimodal peaks around 50\u201380\u2009years. Patients with acute pancreatitis had a higher proportion of alcohol consumption than those without acute pancreatitis. ROC curve analysis showed age and pH as significant factors; however, their predictive power was not high.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The incidence of acute pancreatitis was 3.8% in patients with accidental hypothermia with core body temperatures \u226432\u00b0C. An association was found between the development of acute pancreatitis and alcohol consumption. No strong predictors of acute pancreatitis were identified.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ams2.70033","type":"journal-article","created":{"date-parts":[[2025,1,4]],"date-time":"2025-01-04T02:14:27Z","timestamp":1735956867000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hypothermia\u2010associated acute pancreatitis: A multicenter prospective observational study"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3615-2132","authenticated-orcid":false,"given":"Masaki","family":"Takahashi","sequence":"first","affiliation":[{"name":"Division of Acute and Critical Care Medicine, Department of Anaesthesiology and Critical Care Medicine Hokkaido University Graduate School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhei","family":"Takauji","sequence":"additional","affiliation":[{"name":"Division of Acute and Critical Care Medicine, Department of Anaesthesiology and Critical Care Medicine Hokkaido University Graduate School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8341-7626","authenticated-orcid":false,"given":"Mineji","family":"Hayakawa","sequence":"additional","affiliation":[{"name":"Division of Acute and Critical Care Medicine, Department of Anaesthesiology and Critical Care Medicine Hokkaido University Graduate School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199412293312607"},{"key":"e_1_2_11_3_1","first-page":"192","article-title":"The evaluation and management of accidental hypothermia","volume":"49","author":"Kempainen RR","year":"2004","journal-title":"Respir Care"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ams2.694"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.4.5895.757"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.35.11.1244"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000489296"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/014107680309600506"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-052200"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2022.12.001"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199811000-00016"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00534-005-1048-2"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2004.031823"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2018.05.008"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2008.5"},{"key":"e_1_2_11_16_1","first-page":"5185","article-title":"Analysis of risk factors and prevention strategies of post\u2010ERCP pancreatitis","volume":"21","author":"Lin Y","year":"2017","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.19411"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118548387"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000001738"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2010.06445.x"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TA.0000074434.39928.72"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(78)90519-3"}],"container-title":["Acute Medicine &amp; 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