{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T04:07:06Z","timestamp":1780718826277,"version":"3.54.1"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:00:00Z","timestamp":1740009600000},"content-version":"vor","delay-in-days":50,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acute Medicine &amp; Surgery"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Aconitum<\/jats:italic>\n                      poisoning can cause severe arrhythmias. We report, for the first time, the detailed blood and urine concentrations of four aconitine alkaloids in a male patient in his 20s who ingested aconite roots with suicidal intent.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>The patient developed refractory torsade de pointes (TdP) and required veno\u2010arterial extracorporeal membrane oxygenation. His TdP resolved 7\u2009h after arrival, with sinus rhythm returning within 12\u2009h. The patient was discharged 6\u2009days later. Subsequent measurements of the four alkaloids over time showed that jesaconitine had the highest serum concentration, with the patient's sinus rhythm returning when the jesaconitine concentration was less than 1\u2009ng\/mL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This report provides valuable insights into the disposition of aconitine alkaloids during severe intoxication. The changes in jesaconitine concentrations over time correlate with clinical symptoms, suggesting that these levels could guide treatment decisions in patients with severe\n                      <jats:italic>Aconitum<\/jats:italic>\n                      poisoning.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ams2.70047","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T03:19:23Z","timestamp":1740021563000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Jesaconitine monitoring in a case of severe aconitum poisoning with torsade de pointes treated via extracorporeal membrane oxygenation"],"prefix":"10.1002","volume":"12","author":[{"given":"Yoshitaka","family":"Tomita","sequence":"first","affiliation":[{"name":"Department of Emergency, Critical Care and Disaster Medicine Showa University School of Medicine  Shinagawa\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2099-1345","authenticated-orcid":false,"given":"Keisuke","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Emergency, Critical Care and Disaster Medicine Showa University School of Medicine  Shinagawa\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asuka","family":"Kaizaki\u2010Mitsumoto","sequence":"additional","affiliation":[{"name":"Department of Toxicology Showa University Graduate School of Pharmacy  Shinagawa\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natsumi","family":"Hattori\u2010Usami","sequence":"additional","affiliation":[{"name":"Department of Toxicology Showa University Graduate School of Pharmacy  Shinagawa\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Numazawa","sequence":"additional","affiliation":[{"name":"Department of Toxicology Showa University Graduate School of Pharmacy  Shinagawa\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Department of Emergency, Critical Care and Disaster Medicine Showa University School of Medicine  Shinagawa\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gen","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Emergency, Critical Care and Disaster Medicine Showa University School of Medicine  Shinagawa\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9558-2570","authenticated-orcid":false,"given":"Kazuyuki","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Emergency, Critical Care and Disaster Medicine Showa University School of Medicine  Shinagawa\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaharu","family":"Yagi","sequence":"additional","affiliation":[{"name":"Department of Emergency, Critical Care and Disaster Medicine Showa University School of Medicine  Shinagawa\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Dohi","sequence":"additional","affiliation":[{"name":"Department of Emergency, Critical Care and Disaster Medicine Showa University School of Medicine  Shinagawa\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13020\u2010021\u201000472\u20109"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v12.i2.399"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.11339\/jtm.25.67"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/31.3.132"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.33160\/yam.2024.08.012"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1626\/jcs.87.76"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/24.5.348"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0379\u20100738(96)01980\u20109"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2012.10.021"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jja2.12624"}],"container-title":["Acute Medicine &amp; Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ams2.70047","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T07:46:24Z","timestamp":1766475984000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ams2.70047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/ams2.70047"],"URL":"https:\/\/doi.org\/10.1002\/ams2.70047","archive":["Portico"],"relation":{},"ISSN":["2052-8817","2052-8817"],"issn-type":[{"value":"2052-8817","type":"print"},{"value":"2052-8817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-09-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70047"}}