{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T10:39:04Z","timestamp":1766486344816,"version":"3.48.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"vor","delay-in-days":184,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acute Medicine &amp; Surgery"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Hydrogen inhalation therapy, a novel therapy for reducing oxidative stress in post\u2010cardiac arrest syndrome, was beneficial for superior mesenteric artery (SMA) occlusion. We assessed the efficacy and feasibility of hydrogen inhalation therapy in swine models of critically ill conditions leading to non\u2010occlusive mesenteric ischemia (NOMI) without acute surgical intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>NOMI was induced in eight 3\u2010 to 4\u2010month\u2010old female swine under general anesthesia. We defined the initiation of epinephrine administration via the SMA as T\u2009=\u20090 and the initiation of phlebotomy as T\u2009=\u2009\u221230 relative to this point. Hemorrhagic shock was induced by combining phlebotomy (T\u2009=\u2009\u221230 to \u221210), continuous systemic norepinephrine administration (T\u2009=\u2009\u221230 to 240), and continuous epinephrine injection through the SMA (T\u2009=\u20090\u2013240). The extent of mesenteric ischemia was assessed through gross observation of the intestinal serosa, biomarkers, intestinal pathology, and computed tomography angiography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Control (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094) and hydrogen (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094) groups with similar baseline characteristics were included. All animals survived until euthanasia (T\u2009=\u2009240). The serosa became dark during local epinephrine administration. At T\u2009=\u2009240, lactate levels in the control and hydrogen groups were 7.4 (4.7\u201311.3) and 5.6 (5.0\u20136.4) mmol\/L, respectively, while median 8\u2010hydroxy\u20102'\u2010deoxyguanosinelevels were 0.15 (0.14\u20130.18) and 0.15 (0.13\u20130.16) ng\/mL. The pH, base excess, and potassium levels were similar. No significant differences existed in the ischemic grade of the intestinal tract at any time or site.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although critically ill conditions can trigger NOMI, the model used in this study did not involve transmural necrosis. Under such conditions, hydrogen inhalation therapy did not reduce histological ischemic damage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ams2.70072","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T08:27:36Z","timestamp":1751617656000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hydrogen inhalation therapy alone may not alleviate intestinal mucosal damage in\n                    <scp>NOMI<\/scp>\n                    without total\u2010layer necrosis: An experimental swine model study"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2019-4247","authenticated-orcid":false,"given":"Yasutaka","family":"Tanaka","sequence":"first","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Jichi Medical University  Shimotsuke Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosuke","family":"Matsumura","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Chiba Emergency and Psychiatric Medical Center  Chiba Japan"},{"name":"Department of Emergency and Critical Care Medicine Chiba University  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosuke","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Chiba University  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8239-8822","authenticated-orcid":false,"given":"Makoto","family":"Aoki","sequence":"additional","affiliation":[{"name":"Division of Traumatology National Defense Medical College Research Institute  Tokorozawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshimitsu","family":"Izawa","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Jichi Medical University  Shimotsuke Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Endo","sequence":"additional","affiliation":[{"name":"Center for Development of Advanced Medical Technology Jichi Medical University  Shimotsuke Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Mato","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Jichi Medical University  Shimotsuke Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM195805012581804"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1272\/jnms.JNMS.2024_91\u2010310"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894\u2010020\u20100754\u2010x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330\u2010001\u20101220\u20102"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2011.03.053"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000004255"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02471520"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/2045\u20109912.260649"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.19\u2010101"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000001620"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.05.165"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.4240\/wjgs.v14.i12.1329"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ams2.982"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1590\/s0102\u201086502010000400003"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1970.01340280030009"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e3181cdc4ae"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2019.03.23"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.011848"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ\u201017\u20100105"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13613\u2010022\u201001092\u20108"}],"container-title":["Acute Medicine &amp; 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