{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T07:49:28Z","timestamp":1766476168297,"version":"3.48.0"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":287,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acute Medicine &amp; Surgery"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Necrotizing fasciitis (NF) is a life\u2010threatening soft tissue infection with rapid progression of necrosis. Early debridement and further surgical procedures are essential, but decision\u2010making is often difficult. Serum interleukin\u20106 (IL\u20106) may serve as a valuable diagnostic parameter for monitoring the patient's state and may help in the selection of further therapeutic procedures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Summary<\/jats:title>\n                    <jats:p>A 52\u2010year\u2010old man presented with a fever and severe pain in his left elbow. Laboratory tests showed streptococcal infection, septic shock, and extremely high IL\u20106 levels. Intensive care, including wide\u2010spectrum antibiotics, rapid debridement, large\u2010scale amputation, and continuous hemodiafiltration using polymethylmethacrylate (PMMA\u2010CHDF), was performed to ensure the patient's survival. The serum IL\u20106 level was constantly monitored to assess the outcomes of therapeutic interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Real\u2010time serum IL\u20106 levels may help assess the immune status of NF patients, guide therapeutic decisions as a part of a comprehensive evaluation, and not hesitate to amputate an extremity to save the patient's life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ams2.70090","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T19:27:03Z","timestamp":1760556423000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Case of Necrotizing Fasciitis in Which Interleukin\u20106 Measurement Helped in the Decision for Large\u2010Scale Amputation of the Left Shoulder and Arm"],"prefix":"10.1002","volume":"12","author":[{"given":"Zuzanna","family":"Granek","sequence":"first","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Aichi Medical University  Nagakute Japan"},{"name":"Faculty of Medicine Medical University of Lodz  Lodz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seina","family":"Osakabe","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Aichi Medical University  Nagakute Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Kajita","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Aichi Medical University  Nagakute Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Irahara","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Aichi Medical University  Nagakute Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Kuge","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Aichi Medical University  Nagakute Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosuke","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Aichi Medical University  Nagakute Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Kai","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Aichi Medical University  Nagakute Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dai","family":"Oishi","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Aichi Medical University  Nagakute 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