{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T07:49:32Z","timestamp":1766476172791,"version":"3.48.0"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":287,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acute Medicine &amp; Surgery"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Necrotizing soft tissue infection caused by Group A \u03b2\u2010hemolytic\n                      <jats:italic>Streptococcus<\/jats:italic>\n                      (GAS) requires early recognition and intervention due to its rapid progression and high mortality. While rapid antigen detection testing (RADT) is primarily designed for GAS pharyngitis diagnosis, its utility in necrotizing soft tissue infections remains limited.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>This series presents three cases of GAS necrotizing soft tissue infection in which RADT provided adjunctive diagnostic information that contributed to surgical management decisions. RADT positivity, combined with clinical findings, facilitated immediate extensive debridement in one case, prompted additional surgical exploration despite the absence of obvious fascial necrosis in another, and provided supportive data for early intervention when local findings worsened in the third case. All patients survived with limb preservation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>While the utility of GAS RADT in necrotizing soft tissue infections is not yet established, this case series suggests its potential value as adjunctive diagnostic information that may contribute to decisions regarding extensive debridement, additional incisions, or the need for careful wound monitoring in anticipation of developing necrosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ams2.70092","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T19:28:19Z","timestamp":1760556499000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rapid Antigen Detection Testing as Supportive Tool in Group A Streptococcal Necrotizing Soft Tissue Infection Management: A Case Series"],"prefix":"10.1002","volume":"12","author":[{"given":"Yutaka","family":"Enomoto","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine Nagasaki Harbor Medical Center  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2011-485X","authenticated-orcid":false,"given":"Yoshihiro","family":"Aoki","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Nagasaki Harbor Medical Center  Nagasaki Japan"},{"name":"Coordination Office for Emergency Medicine and International Response, Acute and Critical Care Center Nagasaki University Hospital  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rina","family":"Akashi","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Nagasaki Harbor Medical Center  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Yoshino","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Nagasaki Harbor Medical Center  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Kuga","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Nagasaki Harbor Medical Center  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuko","family":"Tachikawa","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Nagasaki Harbor Medical Center  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Sugawara","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Nagasaki Harbor Medical Center  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Hiraoka","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Nagasaki Harbor Medical Center  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kensuke","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Nagasaki Harbor Medical Center  Nagasaki Japan"},{"name":"Coordination Office for Emergency Medicine and International Response, Acute and Critical Care Center Nagasaki University Hospital  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuhei","family":"Yamano","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Nagasaki Harbor Medical Center  Nagasaki Japan"},{"name":"Coordination Office for Emergency Medicine and International Response, Acute and Critical Care Center Nagasaki University Hospital  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoi","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Nagasaki Harbor Medical Center  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Hayakawa","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Nagasaki Harbor Medical Center  Nagasaki Japan"},{"name":"Coordination Office for Emergency Medicine and International Response, Acute and Critical Care Center Nagasaki University Hospital  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Tasaki","sequence":"additional","affiliation":[{"name":"Acute and Critical Care Center Nagasaki University Hospital  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2008.09.006"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(96)70065-3"},{"key":"e_1_2_10_4_1","first-page":"103","article-title":"A Case of Severe Necrotizing Fasciitis in Which a Rapid Diagnostic Kit for Group A Streptococci Allowed Early Surgical Intervention and Limb Preservation","volume":"10","author":"Tsuge I.","year":"2019","journal-title":"Japanese Journal of Surgical Wound Care"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010502.pub2"},{"key":"e_1_2_10_6_1","first-page":"253","article-title":"Response to Infections Requiring Surgical Critical Care: Utility of Early Extensive Debridement and Rapid Antigen Detection Testing for Necrotizing Soft Tissue Infections Caused by Group A \u03b2\u2010Hemolytic Streptococcus","volume":"7","author":"Esaki M.","year":"2017","journal-title":"Japanese Journal of Acute Care Surgery (Web)"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1308\/rcsann.2017.0053"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1600673"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1086\/427286"},{"key":"e_1_2_10_10_1","article-title":"Group G Streptococcal Necrotizing Soft Tissue Infection: A Pitfall of Rapid Antigen Detection Test for Group A","volume":"22","author":"Tsuge I.","year":"2022","journal-title":"Eplasty"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000003793"}],"container-title":["Acute Medicine &amp; Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ams2.70092","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T07:44:49Z","timestamp":1766475889000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ams2.70092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/ams2.70092"],"URL":"https:\/\/doi.org\/10.1002\/ams2.70092","archive":["Portico"],"relation":{},"ISSN":["2052-8817","2052-8817"],"issn-type":[{"type":"print","value":"2052-8817"},{"type":"electronic","value":"2052-8817"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2025-04-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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