{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:23:14Z","timestamp":1790245394014,"version":"4.1.0"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T00:00:00Z","timestamp":1760745600000},"content-version":"vor","delay-in-days":290,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acute Medicine &amp; Surgery"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Upper extremity deep vein thrombosis (UEDVT) is rare, accounting for 4%\u201310% of all DVT cases. Central venous catheterization and malignancy are primary risk factors, making cases without these factors uncommon.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>A 76\u2010year\u2010old woman with hypertension was admitted with sepsis. She had no history of central venous catheterization. Contrast\u2010enhanced CT revealed asymptomatic UEDVT in the left subclavian and brachiocephalic veins, lower extremity DVT, and bilateral pulmonary embolism. D\u2010dimer was elevated. Tests showed elevated homocysteine; other thrombophilic screening was negative. No malignancy was detected. Heparin followed by edoxaban achieved complete resolution on follow\u2010up imaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In elderly patients with elevated D\u2010dimer and multiple DVT risk factors, particularly with sepsis or limited cardiopulmonary reserve, upper extremity imaging may be warranted even without UEDVT\u2010specific symptoms. Asymptomatic UEDVT may have clinical implications for management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ams2.70093","type":"journal-article","created":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T16:12:56Z","timestamp":1760803976000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Incidental Detection of Asymptomatic Upper Extremity Deep Vein Thrombosis in an Elderly Patient With Pulmonary Embolism"],"prefix":"10.1002","volume":"12","author":[{"given":"Shuhei","family":"Uotani","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine Nagasaki Harbor Medical Center  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2011-485X","authenticated-orcid":false,"given":"Yoshihiro","family":"Aoki","sequence":"additional","affiliation":[{"name":"Coordination Office for Emergency Medicine and International Response, Acute and Critical Care Center Nagasaki University Hospital  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9267-6977","authenticated-orcid":false,"given":"Keita","family":"Iyama","sequence":"additional","affiliation":[{"name":"Acute and Critical Care Center Nagasaki University Hospital  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuko","family":"Tachikawa","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Nagasaki Harbor Medical Center  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Sugawara","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Nagasaki Harbor Medical Center  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensuke","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Coordination Office for Emergency Medicine and International Response, Acute and Critical Care Center Nagasaki University Hospital  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhei","family":"Yamano","sequence":"additional","affiliation":[{"name":"Coordination Office for Emergency Medicine and International Response, Acute and Critical Care Center Nagasaki University Hospital  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Hayakawa","sequence":"additional","affiliation":[{"name":"Coordination Office for Emergency Medicine and International Response, Acute and Critical Care Center Nagasaki University Hospital  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Tasaki","sequence":"additional","affiliation":[{"name":"Acute and Critical Care Center Nagasaki University Hospital  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043169"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2006.06.046"},{"key":"e_1_2_9_4_1","first-page":"244","article-title":"Deep Vein Thrombosis of the Upper Extremity","volume":"114","author":"Heil J.","year":"2017","journal-title":"Deutsches \u00c4rzteblatt International"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.698336"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.32596\/ejcm.galenos.2021-06-039"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH07-08-0485"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2016.11.007"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0262522"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-1432"},{"key":"e_1_2_9_11_1","volume-title":"Guideline on the Management of Pulmonary Thromboembolism, Deep Venous Thrombosis, and Pulmonary Hypertension","author":"Japanese Circulation Society\/Japanese Pulmonary Circulation and Pulmonary Hypertension Society","year":"2025"}],"container-title":["Acute Medicine &amp; Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ams2.70093","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T07:44:48Z","timestamp":1766475888000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ams2.70093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/ams2.70093"],"URL":"https:\/\/doi.org\/10.1002\/ams2.70093","archive":["Portico"],"relation":{},"ISSN":["2052-8817","2052-8817"],"issn-type":[{"value":"2052-8817","type":"print"},{"value":"2052-8817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2025-03-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70093"}}