{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T08:51:51Z","timestamp":1767948711257,"version":"3.49.0"},"reference-count":7,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acute Medicine &amp; Surgery"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Disseminated cryptococcosis is a severe, high\u2010mortality opportunistic infection with systemic effects, particularly in immunocompromised patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>Herein, we report a rare case of fulminant disseminated cryptococcosis in a 32\u2010year\u2010old male with undiagnosed advanced human immunodeficiency virus\/acquired immune deficiency syndrome who rapidly developed multi\u2010organ failure, refractory shock, and cardiac arrest within 21\u2009h of admission, necessitating veno\u2010arterial extracorporeal membrane oxygenation. Despite resuscitative efforts, the patient died on Day 6.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case highlights the accelerated progression of disseminated cryptococcosis in patients with profound immunosuppression and the unique autopsy findings of extensive myocardial cryptococcal infiltration and microemboli, suggesting a contribution to acute refractory shock.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ams2.70112","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T07:32:44Z","timestamp":1767943964000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fatal Outcome due to Disseminated Cryptococcosis in a Patient With\n                    <scp>HIVrequiring<\/scp>\n                    Veno\u2010Arterial Extracorporeal Membrane Oxygenation: A Case Report"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7884-916X","authenticated-orcid":false,"given":"Taisei","family":"Sasamoto","sequence":"first","affiliation":[{"name":"Trauma and Acute Critical Care Centre Institute of Science Tokyo Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Kawahara","sequence":"additional","affiliation":[{"name":"Trauma and Acute Critical Care Centre Institute of Science Tokyo Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Matsui","sequence":"additional","affiliation":[{"name":"Trauma and Acute Critical Care Centre Institute of Science Tokyo Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Morishita","sequence":"additional","affiliation":[{"name":"Trauma and Acute Critical Care Centre Institute of Science Tokyo Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"e495","DOI":"10.1016\/S1473-3099(23)00731-4","article-title":"Global Guideline for the Diagnosis and Management of Cryptococcosis: An Initiative of the ECMM and ISHAM in Cooperation With the ASM","volume":"24","author":"Chang C. C.","year":"2024","journal-title":"Lancet Infectious Diseases"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1056\/NEJMra2311057","article-title":"Cryptococcal Disease in Diverse Hosts","volume":"390","author":"Meya D. B.","year":"2024","journal-title":"New England Journal of Medicine"},{"key":"e_1_2_10_4_1","first-page":"891","article-title":"Estimation of the Global Burden of Cryptococcal Meningitis Among Persons With HIV\/AIDS","volume":"23","author":"Park B. J.","year":"2009","journal-title":"Aids"},{"issue":"25","key":"e_1_2_10_5_1","first-page":"246","article-title":"Venoarterial Extracorporeal Membrane Oxygenation as Mechanical Circulatory Support in Adult Septic Shock: A Systematic Review and Meta\u2010Analysis With Individual Participant Data Meta\u2010Regression Analysis","volume":"14","author":"Vieillard\u2010Baron A.","year":"2021","journal-title":"Critical Care"},{"key":"e_1_2_10_6_1","doi-asserted-by":"crossref","DOI":"10.1177\/2632010X221078234","article-title":"Disseminated Cryptococcal Infection in HIV\u2010Infected Patients: A Retrospective Clinicopathological Review of 4 Autopsy Cases","volume":"15","author":"Khaba M. C.","year":"2022","journal-title":"Clinical Pathology"},{"key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1093\/cid\/ciad440","article-title":"Oral Lipid Nanocrystal Amphotericin B for Cryptococcal Meningitis: A Randomized Clinical Trial","volume":"77","author":"Boulware D. R.","year":"2023","journal-title":"Clinical Infectious Diseases"},{"key":"e_1_2_10_8_1","doi-asserted-by":"crossref","DOI":"10.1128\/JCM.00860-21","article-title":"Evaluation of the Diagnostic Performance of a Semiquantitative Cryptococcal Antigen Point\u2010Of\u2010Care Assay Among HIV\u2010Infected Persons With Cryptococcal Meningitis","volume":"59","author":"Kandole T. K.","year":"2021","journal-title":"Journal of Clinical Microbiology"}],"container-title":["Acute Medicine &amp; Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ams2.70112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T07:32:46Z","timestamp":1767943966000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ams2.70112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/ams2.70112"],"URL":"https:\/\/doi.org\/10.1002\/ams2.70112","archive":["Portico"],"relation":{},"ISSN":["2052-8817","2052-8817"],"issn-type":[{"value":"2052-8817","type":"print"},{"value":"2052-8817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-07-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70112"}}