{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T05:58:26Z","timestamp":1780984706438,"version":"3.54.1"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":158,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acute Medicine &amp; Surgery"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aimed to evaluate whether early enteral nutrition can be administered without increasing gastrointestinal complications in patients receiving mechanical circulatory support.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective observational study was conducted at a tertiary hospital in Japan. We consecutively included adult patients supported with intra\u2010aortic balloon pumping alone or with both intra\u2010aortic balloon pumping and veno\u2010arterial extracorporeal membrane oxygenation who remained in the intensive care unit for &gt;\u20091\u2009week between January 2010 and December 2019. Patients were divided into an early group (enteral nutrition initiated within 48\u2009h of admission) and a late group (enteral nutrition initiated after 48\u2009h). The study endpoints were the amount of energy administered in each group and the frequency of gastrointestinal complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty\u2010five patients were eligible, including 16 in the early group and 39 in the late group. Time from admission to enteral nutrition initiation was 1.5 (1\u20132) days in the early group and 4.5 (3\u20136.5) days in 24 late\u2010group patients who received enteral nutrition. Energy administered per ideal body weight increased earlier in the early group and differed significantly from Day 2 to Day 5, whereas no significant difference was observed after Day 6. No significant differences were found in gastrointestinal complications or mortality between groups; mortality was 7 patients (35%) in the early group and 17 patients (44%) in the late group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest that early enteral nutrition may be a feasible option in carefully selected patients receiving mechanical circulatory support during intensive care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ams2.70132","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T05:10:42Z","timestamp":1780981842000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Feasibility of Early Enteral Nutrition in Patients Under Mechanical Circulatory Support"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2234-697X","authenticated-orcid":false,"given":"Chikai","family":"Mitsuhara","sequence":"first","affiliation":[{"name":"Department of Traumatology and Acute Critical Medicine The University of Osaka Graduate School of Medicine  Suita Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0631-9365","authenticated-orcid":false,"given":"Kentaro","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Traumatology and Acute Critical Medicine The University of Osaka Graduate School of Medicine  Suita Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4101-0419","authenticated-orcid":false,"given":"Takeshi","family":"Ebihara","sequence":"additional","affiliation":[{"name":"Department of Traumatology and Acute Critical Medicine The University of Osaka Graduate School of Medicine  Suita Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ogura","sequence":"additional","affiliation":[{"name":"Department of Traumatology and Acute Critical Medicine The University of Osaka Graduate School of Medicine  Suita Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Oda","sequence":"additional","affiliation":[{"name":"Department of Traumatology and Acute Critical Medicine The University of Osaka Graduate School of Medicine  Suita Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,8]]},"reference":[{"issue":"1","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/jpen.2267","article-title":"Guidelines for the Provision of Nutrition Support Therapy in the Adult Critically Ill Patient: The American Society for Parenteral and Enteral Nutrition","volume":"46","author":"Compher C.","year":"2022","journal-title":"JPEN Journal of Parenteral and Enteral Nutrition"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1016\/j.clnu.2023.07.011","article-title":"ESPEN Practical and Partially Revised Guideline: Clinical Nutrition in the Intensive Care Unit","volume":"42","author":"Singer P.","year":"2023","journal-title":"Clinical Nutrition"},{"issue":"1","key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s40560-025-00785-z","article-title":"The Japanese Critical Care Nutrition Guideline 2024","volume":"13","author":"Nakamura K.","year":"2025","journal-title":"Journal of Intensive Care"},{"key":"e_1_2_10_5_1","unstructured":"World Health Organization \u201cDiarrhoeal Disease \u201d(2024) accessed February 10 2025 http:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/diarrhoeal\u2010disease."},{"issue":"6722","key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1136\/bmj.300.6722.439","article-title":"Detection of Pseudodiarrhoea by Simple Clinical Assessment of Intestinal Transit Rate","volume":"300","author":"O'Donnell L. 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