{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T06:27:28Z","timestamp":1786602448607,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":223,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acute Medicine &amp;amp; Surgery"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess the current status of initial fluid administration in patients with cardiogenic shock.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with cardiogenic shock registered in the Japanese Circulation Society Cardiovascular Shock Registry were analyzed to investigate real\u2010world fluid resuscitation status upon hospital arrival. From this registry, patients with and without pulmonary congestion were investigated to identify differences in fluid administration. Additionally, the 30\u2010day mortality rate between the groups was examined on the basis of the initial fluid volume administered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 586 patients with cardiogenic shock were included. Initial fluid resuscitation within 30\u2009min after hospital arrival was administered to 568 (96.9%) patients. In multivariate logistic regression for 30\u2010day mortality, older age, lower systolic blood pressure, and a fluid volume of 1001\u20132000\u2009mL within 30\u2009min after hospital arrival were significant predictors. The 30\u2010day mortality rate in patients with pulmonary congestion (442 patients) was higher than that in patients without pulmonary congestion (144 patients). However, there was no difference in the 30\u2010day mortality rate between the groups based on the initial fluid volume administered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Initial fluid administration in patients with cardiogenic shock is common practice. Although patients with pulmonary congestion had higher overall 30\u2010day mortality, the volume of initial fluid administered after hospital arrival was not associated with worse 30\u2010day mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ams2.70157","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T05:39:21Z","timestamp":1786599561000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Impact of Initial Fluid Resuscitation in Patients With Cardiogenic Shock"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0943-357X","authenticated-orcid":false,"given":"Takashi","family":"Yokota","sequence":"first","affiliation":[{"name":"Department of Emergency Disaster and General Medicine Hirosaki University Graduate School of Medicine  Hirosaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4294-325X","authenticated-orcid":false,"given":"Kana","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Department of Emergency Disaster and General Medicine Hirosaki University Graduate School of Medicine  Hirosaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiko","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Emergency Disaster and General Medicine Hirosaki University Graduate School of Medicine  Hirosaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6490-527X","authenticated-orcid":false,"given":"Masato","family":"Naraoka","sequence":"additional","affiliation":[{"name":"Department of Emergency Disaster and General Medicine Hirosaki University Graduate School of Medicine  Hirosaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhiro","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Emergency Disaster and General Medicine Hirosaki University Graduate School of Medicine  Hirosaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eizo","family":"Tachibana","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kawaguchi Municipal Medical Center  Kawaguchi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshio","family":"Tahara","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine National Cerebral and Cardiovascular Center  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3637-2095","authenticated-orcid":false,"given":"Naohiro","family":"Yonemoto","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Faculty of Medicine University of Toyama  Toyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4563-304X","authenticated-orcid":false,"given":"Tetsuya","family":"Matoba","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4849-8234","authenticated-orcid":false,"given":"Tsukasa","family":"Yagi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Nihon University Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Hanada","sequence":"additional","affiliation":[{"name":"Department of Emergency Disaster and General Medicine Hirosaki University Graduate School of Medicine  Hirosaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1056\/NEJMoa1703058","article-title":"Time to Treatment and Mortality During Mandated Emergency Care for Sepsis","volume":"376","author":"Seymour C. 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L.","year":"2013","journal-title":"New England Journal of Medicine"},{"key":"e_1_2_10_13_1","first-page":"52","article-title":"Experts' Recommendations for the Management of Adult Patients With Cardiogenic Shock","volume":"5","author":"Levy B.","year":"2015","journal-title":"Annals of Intensive Care"},{"key":"e_1_2_10_14_1","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1253\/circj.CJ-16-0125","article-title":"Characteristics and Predictors of Mortality in Patients With Cardiovascular Shock in Japan\u2014Results From the Japanese Circulation Society Cardiovascular Shock Registry","volume":"80","author":"Ueki Y.","year":"2016","journal-title":"Circulation Journal"},{"key":"e_1_2_10_15_1","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1007\/s00134-014-3525-z","article-title":"Consensus on Circulatory Shock and Hemodynamic Monitoring. Task Force of the European Society of Intensive Care Medicine","volume":"40","author":"Cecconi M.","year":"2014","journal-title":"Intensive Care Medicine"},{"key":"e_1_2_10_16_1","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1253\/circj.CJ-25-0002","article-title":"JCS\/JHFS 2025 Guideline on Diagnosis and Treatment of Heart Failure","volume":"89","author":"Kitai T.","year":"2025","journal-title":"Circulation Journal: Official Journal of the Japanese Circulation Society"},{"key":"e_1_2_10_17_1","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1001\/jama.2012.294","article-title":"Prehospital Epinephrine Use and Survival Among Patients With Out\u2010Of\u2010Hospital Cardiac Arrest","volume":"307","author":"Hagihara A.","year":"2012","journal-title":"JAMA"},{"key":"e_1_2_10_18_1","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1186\/s13054-014-0533-x","article-title":"Prehospital Intravenous Access and Fluid Resuscitation in Severe Sepsis: An Observational Cohort Study","volume":"18","author":"Seymour C. 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