{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T07:15:00Z","timestamp":1788333300078,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":243,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP26K11903"],"award-info":[{"award-number":["JP26K11903"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011692","name":"General Insurance Association of Japan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011692","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acute Medicine &amp; Surgery"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>DataVerse Japan is a multi\u2010institutional clinical data platform that retains all exportable clinical information from each participating center's information systems and generates analysis\u2010ready datasets for each research question. This study aimed to describe its design, participating centers, data composition, and patient profile, and to characterize its data quality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The platform captures clinical information from each center's information systems, currently the electronic health record (EHR), which incorporates patient data management system (PDMS) data and claims data; reshapes the records into a common five\u2010column long\u2010format (Code, Day, Time, Variable, Value); and stores them as relationally linked. rds objects. We summarized admissions to the participating centers between January 2016 and December 2025.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Four emergency and critical care centers contributed 41,173 admissions from 38,287 individuals and 644,838 patient\u2010days. The platform contains approximately 45 million vital sign records, 30 million laboratory records, and 32 million claims records. Median patient age was 70\u2009years (IQR 49\u201381), and in\u2010hospital mortality was 16.3%. Admission\u2010level presence coverage, defined as the proportion of admissions with at least one record in a category, varied substantially by category, center, and year and improved after EHR and PDMS upgrades.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>DataVerse Japan provides a continuously updated multi\u2010institutional clinical data platform that expands its participating centers over time. The coverage and validation metrics reported here allow investigators to judge whether the platform is suitable for a specific research question in emergency and critical care medicine in Japan.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ams2.70159","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T06:42:14Z","timestamp":1788331334000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Profile and Data Quality of\n                    <scp>DataVerse<\/scp>\n                    Japan: A Multi\u2010Institutional Clinical Data Platform for Emergency and Critical Care Research"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4101-0419","authenticated-orcid":false,"given":"Takeshi","family":"Ebihara","sequence":"first","affiliation":[{"name":"Department of Traumatology and Acute Critical Medicine, Graduate School of Medicine The University of Osaka  Suita, Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5530-806X","authenticated-orcid":false,"given":"Shunichiro","family":"Nakao","sequence":"additional","affiliation":[{"name":"Department of Traumatology and Acute Critical Medicine, Graduate School of Medicine The University of Osaka  Suita, Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryota","family":"Nukiwa","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Hachinohe City Hospital  Hachinohe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8618-0385","authenticated-orcid":false,"given":"Hiroshi","family":"Matsuura","sequence":"additional","affiliation":[{"name":"Emergency and Critical Care Center, Osaka Prefectural Nakakawachi Emergency and Critical Care Center  Higashi\u2010Osaka, Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0881-698X","authenticated-orcid":false,"given":"Koichi","family":"Inukai","sequence":"additional","affiliation":[{"name":"Department of Trauma and Critical Care Medicine Sakai City Medical Center  Sakai, Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Yoneda","sequence":"additional","affiliation":[{"name":"Department of Traumatology and Acute Critical Medicine, Graduate School of Medicine The University of Osaka  Suita, Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3861-6444","authenticated-orcid":false,"given":"Shigeto","family":"Seno","sequence":"additional","affiliation":[{"name":"Department of Bioinformatic Engineering, Graduate School of Information Science and Technology The University of Osaka  Suita, Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8254-3716","authenticated-orcid":false,"given":"Jun","family":"Oda","sequence":"additional","affiliation":[{"name":"Department of Traumatology and Acute Critical Medicine, Graduate School of Medicine The University of Osaka  Suita, Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41597-022-01899-x","article-title":"MIMIC\u2010IV, a Freely Accessible Electronic Health Record Dataset","volume":"10","author":"Johnson A. E. W.","year":"2023","journal-title":"Scientific Data"},{"key":"e_1_2_12_3_1","doi-asserted-by":"crossref","DOI":"10.1038\/sdata.2018.178","article-title":"The eICU Collaborative Research Database, a Freely Available Multi\u2010Center Database for Critical Care Research","volume":"5","author":"Pollard T. J.","year":"2018","journal-title":"Scientific Data"},{"key":"e_1_2_12_4_1","doi-asserted-by":"crossref","first-page":"e563","DOI":"10.1097\/CCM.0000000000004916","article-title":"Sharing ICU Patient Data Responsibly Under the Society of Critical Care Medicine\/European Society of Intensive Care Medicine Joint Data Science Collaboration: The Amsterdam University Medical Centers Database (AmsterdamUMCdb) Example","volume":"49","author":"Thoral P. J.","year":"2021","journal-title":"Critical Care Medicine"},{"key":"e_1_2_12_5_1","volume-title":"HiRID, a High Time\u2010Resolution ICU Dataset (Version 1.1.1)","author":"Faltys M.","year":"2021"},{"key":"e_1_2_12_6_1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.37737\/ace.24011","article-title":"Updated Information on NDB","volume":"6","author":"Yasunaga H.","year":"2024","journal-title":"Ann. Clin. Epidemiol"},{"key":"e_1_2_12_7_1","doi-asserted-by":"crossref","first-page":"106","DOI":"10.37737\/ace.24015","article-title":"Updated Information on the Diagnosis Procedure Combination Data","volume":"6","author":"Yasunaga H.","year":"2024","journal-title":"Ann. Clin. Epidemiol"},{"key":"e_1_2_12_8_1","doi-asserted-by":"crossref","first-page":"689","DOI":"10.2147\/CLEP.S359072","article-title":"Existing Data Sources for Clinical Epidemiology: Database of the National Hospital Organization in Japan","volume":"14","author":"Kanazawa N.","year":"2022","journal-title":"Clinical Epidemiology"},{"key":"e_1_2_12_9_1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s40801-022-00296-5","article-title":"Context and Considerations for Use of Two Japanese Real\u2010World Databases in Japan: Medical Data Vision and Japanese Medical Data Center","volume":"9","author":"Laurent T.","year":"2022","journal-title":"Drugs \u2010 Real World Outcome"},{"key":"e_1_2_12_10_1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.37737\/ace.24009","article-title":"A New Electronic Medical Record Database Linked to Claims Data and Discharge Abstract Data (The RWD Database) in Japan: Study Design and Profile","volume":"6","author":"Okumura Y.","year":"2024","journal-title":"Ann. Clin. Epidemiol"},{"key":"e_1_2_12_11_1","doi-asserted-by":"crossref","DOI":"10.1002\/ams2.847","article-title":"Mapping Publications Using the Japan Trauma Data Bank: Scoping Review of the International Literature","volume":"10","author":"Nakao S.","year":"2023","journal-title":"Acute Medicine & Surgery"},{"key":"e_1_2_12_12_1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jcrc.2019.09.004","article-title":"The Japanese Intensive Care PAtient Database (JIPAD): A National Intensive Care Unit Registry in Japan","volume":"55","author":"Irie H.","year":"2020","journal-title":"Journal of Critical Care"},{"key":"e_1_2_12_13_1","first-page":"98","article-title":"DataVerse Japan: Construction and Utilization of a Research Infrastructure Based on Multi\u2010Institutional Comprehensive Clinical Information","volume":"37","author":"Ebihara T.","year":"2026","journal-title":"Journal of the Japan Association for Acute Medicine"},{"key":"e_1_2_12_14_1","doi-asserted-by":"crossref","DOI":"10.1002\/ams2.70148","article-title":"Early Oral\/Enteral Feeding and Rehabilitation Are Associated With Lower PIICS Incidence: A Propensity Score\u2010Matched Single Center Study","volume":"13","author":"Yoneda K.","year":"2026","journal-title":"Acute Medicine & Surgery"},{"key":"e_1_2_12_15_1","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","article-title":"Global, Regional, and National Sepsis Incidence and Mortality, 1990\u20132017: Analysis for the Global Burden of Disease Study","volume":"395","author":"Rudd K. E.","year":"2020","journal-title":"Lancet"},{"key":"e_1_2_12_16_1","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis\u20103)","volume":"315","author":"Singer M.","year":"2016","journal-title":"JAMA"},{"key":"e_1_2_12_17_1","doi-asserted-by":"crossref","DOI":"10.1002\/ams2.906","article-title":"Challenges Hindering Emergency Physicians' Involvement in Multicenter Collaborative Studies in Japan: A Nationwide Survey Analysis","volume":"10","author":"Yasuda M.","year":"2023","journal-title":"Acute Medicine & Surgery"},{"key":"e_1_2_12_18_1","unstructured":"Ministry of Education Culture Sports Science and Technology of Japan \u201cSurvey on Working Conditions of Physicians at University Hospitals \u201d(2026) https:\/\/www.mext.go.jp\/a_menu\/koutou\/iryou\/2023031_00003.htm. [in Japanese]."},{"key":"e_1_2_12_19_1","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1186\/s13054-025-05448-x","article-title":"Accuracy of the Modified Global Burden of Disease International Classification of Diseases Coding Methods for Identifying Sepsis: A Prospective Multicentre Cohort Study","volume":"29","author":"Kumar A.","year":"2025","journal-title":"Critical Care"},{"key":"e_1_2_12_20_1","article-title":"Accuracy of International Classification of Diseases, 10th Revision Codes for Identifying Sepsis: A Systematic Review and Meta\u2010Analysis","volume":"4","author":"Liu B.","year":"2022","journal-title":"Crit. Care Explor"},{"key":"e_1_2_12_21_1","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1136\/jamia.1999.0060478","article-title":"Organization of Heterogeneous Scientific Data Using the EAV\/CR Representation","volume":"6","author":"Nadkarni P. M.","year":"1999","journal-title":"Journal of the American Medical Informatics Association"},{"key":"e_1_2_12_22_1","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.ijmedinf.2006.09.023","article-title":"Guidelines for the Effective Use of Entity\u2010Attribute\u2010Value Modeling for Biomedical Databases","volume":"76","author":"Dinu V.","year":"2007","journal-title":"International Journal of Medical Informatics"}],"container-title":["Acute Medicine &amp; Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ams2.70159","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ams2.70159","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ams2.70159","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T06:42:18Z","timestamp":1788331338000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ams2.70159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/ams2.70159"],"URL":"https:\/\/doi.org\/10.1002\/ams2.70159","archive":["Portico"],"relation":{},"ISSN":["2052-8817","2052-8817"],"issn-type":[{"value":"2052-8817","type":"print"},{"value":"2052-8817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2026-06-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70159"}}