{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T08:33:38Z","timestamp":1793003618222,"version":"4.5.0"},"reference-count":8,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"vor","delay-in-days":292,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP26K11903"],"award-info":[{"award-number":["JP26K11903"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acute Medicine &amp;amp; Surgery"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acute nicotine intoxication can cause cardiac arrest. We report a case of cardiac arrest managed with veno\u2010arterial extracorporeal membrane oxygenation (VA\u2010ECMO) alongside serial serum nicotine monitoring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>A 36\u2010year\u2010old woman collapsed after ingesting an unknown amount of liquid nicotine, up to 20\u2009g. Emergency medical services found her in cardiac arrest with pulseless electrical activity (PEA). On arrival, she remained in cardiac arrest with PEA\/asystole and severe acidosis, and VA\u2010ECMO was established 82\u2009min after ingestion. Cardiac function gradually improved, and VA\u2010ECMO was discontinued on Day 3. However, she died on Day 28 from post\u2010cardiac arrest brain injury. Liquid chromatography\u2013mass spectrometry (LC\/MS) revealed an admission serum nicotine concentration of 6.44\u2009\u03bcg\/mL, declining to 0.057\u2009\u03bcg\/mL within 18\u2009h. This decline paralleled hemodynamic recovery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although neurological outcome was unfavorable, VA\u2010ECMO may provide temporary circulatory support during the toxic phase of massive nicotine intoxication.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ams2.70173","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T06:29:51Z","timestamp":1792564191000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Serial Serum Nicotine Concentration During\n                    <scp>VA<\/scp>\n                    \u2010\n                    <scp>ECMO<\/scp>\n                    for Nicotine\u2010Induced Cardiac Arrest: A Case Report"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4723-453X","authenticated-orcid":false,"given":"Kensuke","family":"Minami","sequence":"first","affiliation":[{"name":"Department of Traumatology and Acute Critical Medicine, Graduate School of Medicine The University of Osaka  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4101-0419","authenticated-orcid":false,"given":"Takeshi","family":"Ebihara","sequence":"additional","affiliation":[{"name":"Department of Traumatology and Acute Critical Medicine, Graduate School of Medicine The University of Osaka  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9348-1629","authenticated-orcid":false,"given":"Kazuo","family":"Harada","sequence":"additional","affiliation":[{"name":"Department of Legal Medicine The University of Osaka Graduate School of Medicine  Osaka Japan"},{"name":"School of Pharmaceutical Sciences The University of Osaka  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hikaru","family":"Tamagawa","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences The University of Osaka  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuto","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Department of Traumatology and Acute Critical Medicine, Graduate School of Medicine The University of Osaka  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5530-806X","authenticated-orcid":false,"given":"Shunichiro","family":"Nakao","sequence":"additional","affiliation":[{"name":"Department of Traumatology and Acute Critical Medicine, Graduate School of Medicine The University of Osaka  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3565-359X","authenticated-orcid":false,"given":"Ryosuke","family":"Takegawa","sequence":"additional","affiliation":[{"name":"Department of Traumatology and Acute Critical Medicine, Graduate School of Medicine The University of Osaka  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5959-4569","authenticated-orcid":false,"given":"Tomoya","family":"Hirose","sequence":"additional","affiliation":[{"name":"Department of Traumatology and Acute Critical Medicine, Graduate School of Medicine The University of Osaka  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Legal Medicine The University of Osaka Graduate School of Medicine  Osaka Japan"},{"name":"The Education and Research Institute for Death Control and Prevention The University of Osaka Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8254-3716","authenticated-orcid":false,"given":"Jun","family":"Oda","sequence":"additional","affiliation":[{"name":"Department of Traumatology and Acute Critical Medicine, Graduate School of Medicine The University of Osaka  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1994.169"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2017.09.003"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40360\u2010019\u20100307\u20105"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2019.1661428"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001161"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.48.113006.094742"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u2010540\u201069248\u20105_2"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jen.2015.04.001"}],"container-title":["Acute Medicine &amp; 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