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Olanexidine gluconate (OLG) was developed in 2015 in Japan to prevent SSI and CRBSI caused by bacteria resistant to CHG and PVP\u2010I. This scoping review aimed to identify the knowledge gap between what is known and what is not known about the disinfection efficacy of OLG. We searched MEDLINE through PubMed, the Cochrane Central Register of Controlled Trials, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), the International Clinical Trials Registry Platform search database, <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>, and the Web\u2010based database of Japanese medical articles for works published to July 18, 2021. Manual reference searches were also carried out. A total of 131 studies were screened. Forty\u2010seven studies were included in this review and classified into two major categories: studies on pharmacological effects and spectrum (<jats:italic>n<\/jats:italic>\u2009=\u200929) and studies on clinical and adverse effects (<jats:italic>n<\/jats:italic>\u2009=\u200918). Olanexidine gluconate showed bactericidal activity against methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic> and vancomycin\u2010resistant enterococci, in addition to common Gram\u2010positive and Gram\u2010negative bacteria. In clinical settings, although there is limited evidence on SSI prevention, 1.5% OLG might be more effective than 10% PVP\u2010I and 1% CHG in preventing SSI. However, the clinical usefulness of OLG is unclear due to the limited number of clinical studies. Also, clinical research is limited to studies targeting SSI prevention, and there are no clinical studies on CRBSI. Further clinical studies are needed on SSI and CRBSI prevention.<\/jats:p>","DOI":"10.1002\/ams2.723","type":"journal-article","created":{"date-parts":[[2022,1,8]],"date-time":"2022-01-08T04:44:42Z","timestamp":1641617082000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Clinical application of skin antisepsis using aqueous olanexidine: a scoping review"],"prefix":"10.1002","volume":"9","author":[{"given":"Yutaro","family":"Shinzato","sequence":"first","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Jichi Medical University Saitama Medical Center  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiryu","family":"Sakihara","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Jichi Medical University Saitama Medical Center  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9035-1466","authenticated-orcid":false,"given":"Yuki","family":"Kishihara","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Jichi Medical University Saitama Medical Center  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1989-656X","authenticated-orcid":false,"given":"Masahiro","family":"Kashiura","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Jichi Medical University Saitama Medical Center  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3153-1595","authenticated-orcid":false,"given":"Hideto","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Jichi Medical University Saitama Medical Center  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7517-162X","authenticated-orcid":false,"given":"Takashi","family":"Moriya","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Jichi Medical University Saitama Medical Center  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-012-0126-8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2015.05.022"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/497833"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2003.03.002"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2017.0904"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)30398-X"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90479-9"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir257"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1086\/318145"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2021.01.017"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-6701(13)60012-2"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn540"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-018-0308-2"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1086\/421946"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.4058\/jsei.34.305"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq212"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/40.2.221"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.2307\/30144238"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhin.1998.0559"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.000979"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b18-00821"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.000870"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05048-14"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.4058\/jsei.33.52"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.080861-0"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30225-5"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.7326\/M18-0850"},{"key":"e_1_2_8_29_1","unstructured":"Otsuka Pharmaceutical Factory ISterilizing Disinfectant for External Skin Olanexidine Disinfectant Solution 1.5% (Olanexidine Gluconate Solution) 2019 [cited 30 Dec 2021]. 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