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The Japanese Clinical Practice Guidelines for the Management of Sepsis and Septic Shock (J\u2010SSCG) 2020 Special Committee created the Japanese Rapid\/Living recommendations on drug management for COVID\u201019 using the experience of creating the J\u2010SSCG.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) approach was used to determine the certainty of the evidence and strength of recommendations. The first edition of this guideline was released on September 9, 2020, and this is the revised edition (version 5.0; released on July 15, 2022). Clinical questions (CQs) were set for the following 10 drugs: favipiravir (CQ1), remdesivir (CQ2), corticosteroids (CQ4), tocilizumab (CQ5), anticoagulants (CQ7), baricitinib (CQ8), casirivimab\/imdevimab (CQ9\u20101), sotrovimab (CQ9\u20102), molnupiravir (CQ10), and nirmatrelvir\/ritonavir (CQ11).<\/jats:p><\/jats:sec><jats:sec><jats:title>Recommendations<\/jats:title><jats:p>Favipiravir is not suggested for all patients with COVID\u201019 (GRADE 2C). Remdesivir is suggested for patients with mild COVID\u201019 who do not require oxygen, and patients with moderate COVID\u201019 requiring supplemental oxygen\/hospitalization (both GRADE 2B). Corticosteroids are recommended for moderate and severe COVID\u201019 (GRADE 1B, 1A). However, their administration is not recommended for mild COVID\u201019 (GRADE 1B). Tocilizumab is suggested for moderate and severe COVID\u201019 (GRADE 2B, 2C). Anticoagulant administration is recommended for moderate and severe COVID\u201019 (Good Practice Statement). Baricitinib is suggested for moderate and severe COVID\u201019 (both GRADE 2C). Casirivimab\/imdevimab and sotrovimab are recommended for mild COVID\u201019 (both GRADE 2C). Molnupiravir and nirmatrelvir\/ritonavir are recommended for mild COVID\u201019 (both GRADE 2C). SARS\u2010CoV\u20102 mutant strains emerge occasionally, and each time, the treatment policy at clinics is forced to change drastically. We ask health\u2010care professionals in the field to refer to the recommendations in these guidelines and use these to keep up to date with COVID\u201019 epidemiological information.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ams2.789","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T09:30:21Z","timestamp":1666171821000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Japanese rapid\/living recommendations on drug management for <scp>COVID<\/scp>\u201019: updated guidelines (July 2022)"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2999-4021","authenticated-orcid":false,"given":"Kazuma","family":"Yamakawa","sequence":"first","affiliation":[{"name":"Department of Emergency and Critical Care Medicine Osaka Medical and Pharmaceutical University  Takatsuki 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